A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization - Silva, Laurie A.; Khomandiak, Solomiia; Ashbrook, Alison W.; Weller, Romy; Heise, Mark T.; Morrison, Thomas E.; Dermody, Terence S. (Journal of Virology, 2014)
Keywords: Alphavirus Infections - metabolism; Amino Acid Substitution; Animals; Arbovirus; Cercopithecus aethiops; Chikungunya Fever; Chikungunya virus; Chikungunya virus - genetics; Chikungunya virus - metabolism; Chikungunya virus - physiology; CHO Cells; Cricetinae; Cricetulus; Endosomes - metabolism; Endosomes - virology; Genotype; Glycosaminoglycans - metabolism; Glycosaminoglycans - pharmacology; Heparitin Sulfate - metabolism; Heparitin Sulfate - pharmacology; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Mutation; Polymorphism, Single Nucleotide; Protein Multimerization; Static Electricity; Vero Cells; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - genetics; Virus Attachment - drug effects; Virus Internalization - drug effects; Virus Replication - drug effects; Virus-Cell Interactions; Asia; Africa