Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 41; pp. 25800 - 25809
• Main Authors: Lau, Shun-Fat, Cao, Han, Fu, Amy K. Y., Ip, Nancy Y.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.10.2020
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Angiogenesis; Antigen presentation; Antigens; Astrocytes; Biological activity; Biological Sciences; Brain; Cell Nucleus - genetics; Dementia disorders; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - metabolism; Female; Gene expression; Gene Expression Profiling; Growth factors; Heterogeneity; Histocompatibility antigen HLA; Humans; Immune response; Immune system; Male; Myelination; Neurodegenerative diseases; Neuroglia - cytology; Neuroglia - metabolism; Neuronal-glial interactions; Neuroprotection; Nuclei (cytology); Oligodendrocytes; Pathogenesis; Prefrontal Cortex - cytology; Prefrontal Cortex - metabolism; Single-Cell Analysis; Transcriptome; myelination; neurodegenerative diseases; synaptic signaling; synapse; angiogenesis

Alzheimer’s disease (AD) is the most common form of dementia but has no effective treatment. A comprehensive investigation of cell type-specific responses and cellular heterogeneity in AD is required to provide precise molecular and cellular targets for therapeutic development. Accordingly, we perfo...