Bone morphogenetic protein 2-induced human dental pulp cell differentiation involves p38 mitogen-activated protein kinase-activated canonical WNT pathway

• Published in: International journal of oral science Vol. 7; no. 2; pp. 95 - 102
• Main Authors: Yang, Jing, Ye, Ling, Hui, Tian-Qian, Yang, Dong-Mei, Huang, Ding-Ming, Zhou, Xue-Dong, Mao, Jeremy J, Wang, Cheng-Lin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2015; Springer Nature B.V; State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China%Center for Craniofacial Regeneration CCR, Columbia University Medical Center, New York, USA; Nature Publishing Group
• Subjects: beta Catenin - metabolism; Bone Morphogenetic Protein 2 - physiology; Cell Differentiation - physiology; Dental Pulp - cytology; Dentistry; Humans; MAP Kinase Signaling System; Medicine; Oral and Maxillofacial Surgery; Original; original-article; Orthopedics; p38丝裂原活化蛋白激酶; Surgical Orthopedics; Wnt Proteins - metabolism; Wnt信号通路; β-catenin; 成骨细胞分化; 牙髓; 诱导蛋白; 酶激活; 骨形态发生蛋白; human dental pulp cells; β-catenin; cell differentiation; bone morphogenetic protein 2; p38; b-catenin

Both bone morphogenetic protein 2（BMP2） and the wingless-type MMTV integration site（WNT）/p-catenin signalling pathway play important roles in odontoblast differentiation and dentinogenesis.Cross-talk between BMP2 and WNT/p-catenin in osteoblast differentiation and bone formation has been identified....