A TRPM7 mutation linked to familial trigeminal neuralgia Omega current and hyperexcitability of trigeminal ganglion neurons

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 38; pp. 1 - 10
• Main Authors: Gualdani, Roberta, Gailly, Philippe, Yuan, Jun-Hui, Yerna, Xavier, Di Stefano, Giulia, Truini, Andrea, Cruccu, Giorgio, Dib-Hajj, Sulayman D., Waxman, Stephen G.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 20.09.2022
• Subjects: Alanine; Alanine - genetics; Biological Sciences; Calcium imaging; Calcium ions; Domains; Firing pattern; Gadolinium; Genetic factors; Genetics; Humans; Hydrophobicity; Ion channels; Male; Membrane potential; Mutation; Neuralgia; Neurons; Neurons - physiology; Pain; Protein Serine-Threonine Kinases - genetics; Threonine; Transient receptor potential proteins; Trigeminal ganglion; Trigeminal Ganglion - physiopathology; Trigeminal nerve; Trigeminal Neuralgia - genetics; TRPM Cation Channels - genetics; TRPM Cation Channels - metabolism; human mutations; trigeminal neuralgia; TRP channels; gating current

Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are sporadic, familial clusters of TN suggest that genetic factors may contribute to this disorder. Whole-exome sequencing in...