The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 28; pp. 1 - 9
• Main Authors: Li, You, Misumi, Ichiro, Shiota, Tomoyuki, Sun, Lu, Lenarcic, Erik M., Kim, Hyejeong, Shirasaki, Takayoshi, Hertel-Wulff, Adriana, Tibbs, Taylor, Mitchell, Joseph E., McKnight, Kevin L., Cameron, Craig E., Moorman, Nathaniel J., McGivern, David R., Cullen, John M., Whitmire, Jason K., Lemon, Stanley M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 12.07.2022
• Subjects: Alanine; Alanine transaminase; Animals; Antiviral activity; Antiviral agents; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Apoptosis; Biological Sciences; Chromosomal Proteins, Non-Histone - metabolism; Crosslinking; DNA-Directed DNA Polymerase - metabolism; Genomes; Hepatitis; Hepatitis A; Hepatitis A - drug therapy; Hepatitis A - metabolism; Hepatitis A - virology; Hepatitis A virus - drug effects; Hepatitis A virus - genetics; Hepatitis A virus - physiology; Humans; Immunoprecipitation; Inflammation; Intrinsically Disordered Proteins - metabolism; Mice; Mice, Mutant Strains; Oral administration; Polyadenine; Polyadenylation; Receptor, Interferon alpha-beta - genetics; Replication; RNA Nucleotidyltransferases - metabolism; RNA viruses; RNA, Viral - biosynthesis; RNA, Viral - genetics; Synthesis; Transcription; Translation; Uridine; Virus Replication - drug effects; Zinc finger proteins; RNA-binding protein; hepatitis A; animal model; antiviral therapy; picornavirus

Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of hospitalizations and hundreds of deaths within the United States in recent years. There is no effective antiviral therapy for hepatitis A, and many aspects of the hepatitis A virus (HAV) replication cycle remain...