The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis - Li, You; Misumi, Ichiro; Shiota, Tomoyuki; Sun, Lu; Lenarcic, Erik M.; Kim, Hyejeong; Shirasaki, Takayoshi; Hertel-Wulff, Adriana; Tibbs, Taylor; Mitchell, Joseph E.; McKnight, Kevin L.; Cameron, Craig E.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2022)
Keywords: Alanine; Alanine transaminase; Animals; Antiviral activity; Antiviral agents; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Apoptosis; Biological Sciences; Chromosomal Proteins, Non-Histone - metabolism; Crosslinking; DNA-Directed DNA Polymerase - metabolism; Genomes; Hepatitis; Hepatitis A; Hepatitis A - drug therapy; Hepatitis A - metabolism; Hepatitis A - virology; Hepatitis A virus - drug effects; Hepatitis A virus - genetics; Hepatitis A virus - physiology; Humans; Immunoprecipitation; Inflammation; Intrinsically Disordered Proteins - metabolism; Mice; Mice, Mutant Strains; Oral administration; Polyadenine; Polyadenylation; Receptor, Interferon alpha-beta - genetics; Replication; RNA Nucleotidyltransferases - metabolism; RNA viruses; RNA, Viral - biosynthesis; RNA, Viral - genetics; Synthesis; Transcription; Translation; Uridine; Virus Replication - drug effects; Zinc finger proteins; RNA-binding protein; hepatitis A; animal model; antiviral therapy; picornavirus