Increased levels of lysosomal cysteinyl cathepsins in human varicose veins: a histology study

• Published in: Thrombosis and haemostasis Vol. 111; no. 2; p. 333
• Main Authors: Xu, Na, Zhang, Yuan-Yuan, Lin, Yan, Bao, Bin, Zheng, Lei, Shi, Guo-Ping, Liu, Jian
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2014
• Subjects: Adult; Biomarkers - analysis; Case-Control Studies; Cathepsins - analysis; Cystatin C - analysis; Endothelial Cells - enzymology; Female; Humans; Immunohistochemistry; Inflammation - enzymology; Inflammation - immunology; Inflammation - pathology; Male; Mast Cells - enzymology; Middle Aged; Muscle, Smooth, Vascular - enzymology; Myocytes, Smooth Muscle - enzymology; Saphenous Vein - enzymology; Saphenous Vein - immunology; Saphenous Vein - pathology; T-Lymphocytes - enzymology; Up-Regulation; Varicose Veins - enzymology; Varicose Veins - immunology; Varicose Veins - pathology; Cysteinyl cathepsin; cystatin C; varicose vein; vascular cell; inflammatory cell

Varicose veins are a major chronic venous disease characterised by extensive remodelling of the extracellular matrix architecture in the vascular wall. Although matrix metalloproteinases have been implicated in these pathologic events, little is known about the functional relevance of other protease...