Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients

• Published in: Cancer letters Vol. 403; pp. 318 - 329
• Main Authors: Logozzi, Mariantonia, Angelini, Daniela F., Iessi, Elisabetta, Mizzoni, Davide, Di Raimo, Rossella, Federici, Cristina, Lugini, Luana, Borsellino, Giovanna, Gentilucci, Alessandro, Pierella, Federico, Marzio, Vittorio, Sciarra, Alessandro, Battistini, Luca, Fais, Stefano
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.09.2017; Elsevier Limited
• Subjects: Acidification; Acidity; Antibiotics; Antigens; Benign; Biomarkers; Biopsy; Cancer; Case-Control Studies; CD81 antigen; Cell culture; Cell Line, Tumor; Cytometry; Early Detection of Cancer; ELISA; Enzyme-Linked Immunosorbent Assay; Exosomes; Exosomes - metabolism; Exosomes - pathology; Extracellular vesicles; Flow Cytometry; Humans; Hydrogen-Ion Concentration; Hypertrophy; Hypotheses; Kallikreins - blood; Male; Malignancy; Melanoma; Metastasis; Middle Aged; Nanomedicine - methods; Nanoparticles; Nanoscale flow cytometry; PCa and BPH; Peripheral blood; Physiology; Plasma; Predictive Value of Tests; Prognosis; Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - pathology; Proteins; PSA; Quantitation; Tumor Microenvironment; Tumors; Up-Regulation; Vesicles; Extracellular vesicles; PCa and BPH; Acidity; Nanoscale flow cytometry; PSA; ELISA

Prostate specific antigen (PSA) test is the most common, clinically validated test for the diagnosis of prostate cancer (PCa). While neoplastic lesions of the prostate may cause aberrant levels of PSA in the blood, the quantitation of free or complexed PSA poorly discriminates cancer patients from t...