Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 13; pp. E2960 - E2969
• Main Authors: Gao, Xinghua, Cao, Qiuhua, Cheng, Yan, Zhao, Dandan, Wang, Zhuo, Yang, Hongbao, Wu, Qijin, You, Linjun, Wang, Yue, Lin, Yanting, Li, Xianjing, Wang, Yun, Bian, Jin-Song, Sun, Dongdong, Kong, Lingyi, Birnbaumer, Lutz, Yang, Yong
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.03.2018
• Series: PNAS Plus
• Subjects: Animals; Antibiotics; Biological Sciences; Blood circulation; Body weight; Colitis; Colitis - etiology; Colitis - pathology; Dextran; Dextran sulfate; Dextran Sulfate - toxicity; Disease Models, Animal; Gastrointestinal Microbiome - immunology; Immune system; Immunity, Innate - immunology; Infiltration; Inflammation - etiology; Inflammation - pathology; Inflammatory bowel disease; Inflammatory bowel diseases; Interleukin 6; Interleukin-6 - physiology; Intestinal microflora; Intestine; Lamina propria; Leukocytes; Leukocytes (neutrophilic); Lymph nodes; Lymphocytes B; Lysozyme; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota; Mucin; Mucin-2 - metabolism; Muramidase - metabolism; PNAS Plus; Sodium; Stat3 protein; STAT3 Transcription Factor - metabolism; Stress; Stress, Physiological; Stresses; Thymus; immune reaction; DSS-induced colitis; chronic stress; gut microbiota; mucin-2

Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6...