Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 30; pp. 17957 - 17964
• Main Authors: Ellebedy, Ali H., Nachbagauer, Raffael, Jackson, Katherine J. L., Dai, Ya-Nan, Han, Julianna, Alsoussi, Wafaa B., Davis, Carl W., Stadlbauer, Daniel, Rouphael, Nadine, Chromikova, Veronika, McCausland, Megan, Chang, Cathy Y., Cortese, Mario, Bower, Mary, Chennareddy, Chakravarthy, Schmitz, Aaron J., Zarnitsyna, Veronika I., Lai, Lilin, Rajabhathor, Arvind, Kazemian, Cheyann, Antia, Rustom, Mulligan, Mark J., Ward, Andrew B., Fremont, Daved H., Boyd, Scott D., Pulendran, Bali, Krammer, Florian, Ahmed, Rafi
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.07.2020
• Subjects: Adjuvants, Immunologic; Antibodies; Antibodies, Viral - immunology; Antibody Formation - immunology; Antibody response; Antibody Specificity - immunology; Avian flu; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biological Sciences; Cross Reactions - immunology; Epitopes; Epitopes, B-Lymphocyte - immunology; Female; Hemagglutinins; Humans; Immunization; Immunization, Secondary; Immunologic Memory; Immunological memory; Influenza; Influenza A Virus, H5N1 Subtype - immunology; Influenza Vaccines - immunology; Influenza, Human - prevention & control; Lymphocytes B; Male; Memory cells; Monoclonal antibodies; Plasma Cells - immunology; Plasma Cells - metabolism; Somatic hypermutation; Stems; Vaccines; Viruses; Young adults; influenza; H5N1; memory; B cells; adjuvant

There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated vaccine. Healthy young adults received two doses of either formulation 3 wk apart. We foun...