Structure-activity relationship of the pro- and anticoagulant effects of Fucus vesiculosus fucoidan

• Published in: Thrombosis and haemostasis Vol. 111; no. 3; p. 429
• Main Authors: Zhang, Z, Till, S, Jiang, C, Knappe, S, Reutterer, S, Scheiflinger, F, Szabo, C M, Dockal, M
• Format: Journal Article
• Language: English
• Published: Germany 2014
• Subjects: Anticoagulants - therapeutic use; Chemical Fractionation; Coagulants - therapeutic use; Factor IX - genetics; Factor VIII - genetics; Fucus; Hemophilia A - genetics; Hemophilia A - therapy; Hemophilia B - genetics; Hemophilia B - therapy; Hemostasis; Humans; Lipoproteins - metabolism; Molecular Structure; Molecular Weight; Partial Thromboplastin Time; Plant Extracts - chemistry; Polysaccharides - chemistry; Polysaccharides - therapeutic use; Protein Binding; Structure-Activity Relationship; Sulfuric Acid Esters - chemistry; Blood coagulation; molecular weight; sulfates; fucoidan; structure-activity relationship

Fucoidan is a highly complex sulfated polysaccharide commonly extracted from brown seaweed. In addition to their many biological activities, fucoidans have recently been demonstrated to inhibit or increase coagulation at different concentration ranges. Their structural features, i.e. molecular weigh...