Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma

• Published in: Cancer letters Vol. 518; pp. 35 - 48
• Main Authors: Zhao, Qitai, Huang, Lan, Qin, Guohui, Qiao, Yamin, Ren, Feifei, Shen, Chunyi, Wang, Shumin, Liu, Shasha, Lian, Jinyao, Wang, Dan, Yu, Weina, Zhang, Yi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.10.2021; Elsevier Limited
• Subjects: Apoptosis; Autocrine signalling; Cancer-associated fibroblasts; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; CD11b antigen; Cell Differentiation - physiology; Cell Line; Cell Line, Tumor; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Cisplatin resistance; Drug resistance; Drug Resistance, Neoplasm - physiology; Esophageal cancer; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - pathology; Esophageal squamous cell carcinoma; Esophageal Squamous Cell Carcinoma - drug therapy; Esophageal Squamous Cell Carcinoma - metabolism; Esophageal Squamous Cell Carcinoma - pathology; Esophagus; Ethics; Exosomes - metabolism; Exosomes - pathology; Extracellular matrix; Fibroblasts; Flow cytometry; Growth factors; Humans; Interleukin 6; Interleukin 6 receptors; Interleukin-6 - metabolism; Lymphocytes; Medical prognosis; Metastases; Metastasis; MicroRNAs; MicroRNAs - metabolism; miRNA; Monocytes; Monocytes - metabolism; Monocytes - pathology; Monocytic myeloid-derived suppressor cells; Myeloid cells; Myeloid Cells - metabolism; Myeloid Cells - pathology; Myeloid-Derived Suppressor Cells - metabolism; Myeloid-Derived Suppressor Cells - pathology; Paracrine signalling; Patients; Proteins; Signal transducing activator of transcription 3; Signal Transduction - physiology; Squamous cell carcinoma; Stat3 protein; STAT3 Transcription Factor - metabolism; Stromal cells; Suppressor cells; Transcription; Tumor cells; Tumors; Beijing China; United States > US; China; Cancer-associated fibroblasts; Esophageal squamous cell carcinoma; Signal transducing activator of transcription 3; Cisplatin resistance; Monocytic myeloid-derived suppressor cells

Drug resistance remains the major obstacle limiting the effectiveness of chemotherapy for esophageal squamous cell carcinoma (ESCC)[1]. However, how stromal cells cooperate with immune cells to contribute to drug resistance is not yet fully understood. In this study, we observed that monocytic myelo...