Single nucleotide variation in exon 11 of canine BRCA2 in healthy and cancerous mammary tissue

• Published in: The veterinary journal (1997) Vol. 184; no. 3; pp. 351 - 356
• Main Authors: Hsu, Wei-Li, Huang, Yi-Hsin, Chang, Tien-Jye, Wong, Min-Liang, Chang, Shih-Chieh
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2010
• Subjects: Animals; BRCA2; Case-Control Studies; Codon; codons; Dog; dog diseases; Dog Diseases - genetics; Dogs; exons; Female; females; gene banks; genes; Genes, BRCA1; Genes, BRCA2; Genetic Predisposition to Disease; Genetic Variation; Genetic variations; genetics; germ cells; mammary glands; Mammary Glands, Animal; Mammary Glands, Animal - metabolism; Mammary Neoplasms, Animal; Mammary Neoplasms, Animal - genetics; Mammary tumour; metabolism; molecular sequence data; Mutation, Missense; Pedigree; Point Mutation; Polymorphism, Single Nucleotide; sequence analysis; single nucleotide polymorphism; Tumour suppressor gene; Tumour suppressor gene; Genetic variations; Mammary tumour; BRCA2; Dog

Germline mutations in the BRCA2 tumour suppressor gene are significant risk indicators of breast cancer in women, especially for hereditary breast cancer. The BRCA2 protein interacts via the BRC (breast cancer) domain with RAD51, an essential component of the cellular machinery for the maintenance o...