Myeloid cell TBK1 restricts inflammatory responses

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 4; pp. 1 - 11
• Main Authors: Gao, Tianxiao, Liu, Ting, Ko, Chun-Jung, Zhang, Lingyun, Joo, Donghyun, Xie, Xiaoping, Zhu, Lele, Li, Yanchuan, Cheng, Xuhong, Sun, Shao-Cong
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 25.01.2022
• Subjects: Ablation; Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - pathology; Animals; Biological Sciences; Biomarkers; Colitis; Colitis - etiology; Colitis - metabolism; Colitis - pathology; Cytokines; Cytokines - genetics; Cytokines - metabolism; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility - immunology; Gene Expression Regulation; Glucose - metabolism; High fat diet; Hypertrophy; IL-1β; Immune system; Immunomodulation - genetics; Inflammation; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; Inflammatory diseases; Insulin; Insulin Resistance; Interleukin 1; Interleukin 1 receptors; Kinases; Macrophages; MAP kinase; Metabolic disorders; Mice; Mice, Knockout; Molecular modelling; Myeloid Cells - immunology; Myeloid Cells - metabolism; NF-κB protein; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Organ Specificity; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Receptors, Interleukin-1 - deficiency; Signal Transduction; Signs and symptoms; metabolic disorders; macrophages; TBK1; inflammation; fatty liver disease

Proinflammatory cytokine production by innate immune cells plays a crucial role in inflammatory diseases, but the molecular mechanisms controlling the inflammatory responses are poorly understood. Here, we show that TANK-binding kinase 1 (TBK1) serves as a vital regulator of proinflammatory macropha...