Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear...

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Published in	The Journal of biological chemistry Vol. 289; no. 46; pp. 31673 - 31681
Main Authors	Bagriantsev, Sviatoslav N., Gracheva, Elena O., Gallagher, Patrick G.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 14.11.2014 American Society for Biochemistry and Molecular Biology
Subjects	Amino Acid Sequence Anemia, Hemolytic, Congenital - genetics Animals Electrophysiological Phenomena Erythrocytes - cytology Humans Hydrops Fetalis - genetics Ion Channels - chemistry Ion Channels - physiology Mice Minireviews Molecular Sequence Data Mutation Neurons, Afferent - metabolism Osteoclasts - cytology Phylogeny Protein Structure, Tertiary Sequence Homology, Amino Acid Neuron Genetic Disease Mechanotransduction Membrane Protein Piezo2 Arthrogryposis Ion Channel Piezo1 Hereditary Xerocytosis Gordon Syndrome Somatosensation
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Abstract	Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature.
AbstractList	Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature. Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature.Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature.
Author	Bagriantsev, Sviatoslav N. Gracheva, Elena O. Gallagher, Patrick G.
Author_xml	– sequence: 1 givenname: Sviatoslav N. surname: Bagriantsev fullname: Bagriantsev, Sviatoslav N. organization: Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 – sequence: 2 givenname: Elena O. surname: Gracheva fullname: Gracheva, Elena O. organization: Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 – sequence: 3 givenname: Patrick G. surname: Gallagher fullname: Gallagher, Patrick G. email: patrick.gallagher@yale.edu organization: Departments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, Connecticut 06520
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Keywords	Neuron Genetic Disease Mechanotransduction Membrane Protein Piezo2 Arthrogryposis Ion Channel Piezo1 Hereditary Xerocytosis Gordon Syndrome Somatosensation
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Snippet	Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has...
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SubjectTerms	Amino Acid Sequence Anemia, Hemolytic, Congenital - genetics Animals Electrophysiological Phenomena Erythrocytes - cytology Humans Hydrops Fetalis - genetics Ion Channels - chemistry Ion Channels - physiology Mice Minireviews Molecular Sequence Data Mutation Neurons, Afferent - metabolism Osteoclasts - cytology Phylogeny Protein Structure, Tertiary Sequence Homology, Amino Acid
Title	Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes
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