Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 4; pp. 1370 - 1377
• Main Authors: Zhang, Suping, Zhang, Han, Ghia, Emanuela M., Huang, Jiajia, Wu, Liufeng, Zhang, Jianchao, Lam, Sharon, Lei, Yang, He, Jinsong, Cui, Bing, Widhopf, George F., Yu, Jian, Schwab, Richard, Messer, Karen, Jiang, Wenqi, Parker, Barbara A., Carson, Dennis A., Kipps, Thomas J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.01.2019
• Series: PNAS Plus
• Subjects: Adenosine Triphosphatases - metabolism; Animals; Antibodies, Monoclonal; Antineoplastic Agents - pharmacology; B-cell lymphoma; Bearing; Biological Sciences; Breast - drug effects; Breast - metabolism; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Cancer; Cell Line, Tumor; Cell self-renewal; Chemotherapy; Drug Resistance, Neoplasm - drug effects; Female; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genes; Guanine nucleotide-binding protein; Heterografts; Homology; Humans; Immunoglobulins; Lymphoma; Metastases; Mice; Monoclonal antibodies; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; NIH 3T3 Cells; Nuclear Proteins - metabolism; Paclitaxel; Paclitaxel - pharmacology; Patients; PNAS Plus; Polycomb Repressive Complex 1 - metabolism; Protein-Serine-Threonine Kinases - metabolism; RAG2 protein; Receptor Tyrosine Kinase-like Orphan Receptors - metabolism; Spheroids; Stem cell transplantation; Stem cells; Transcription activation; Transcription Factors - metabolism; Tumors; Tyrosine; Xenografts; Xenotransplantation; Yes-associated protein; ROR1-signaling; cirmtuzumab; ROR1; chemotherapy; breast-cancer stem cells

Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis. Breast cancer cells that express the type I tyrosine kinaselike orphan receptor ROR1 also may ha...