Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody - Zhang, Suping; Zhang, Han; Ghia, Emanuela M.; Huang, Jiajia; Wu, Liufeng; Zhang, Jianchao; Lam, Sharon; Lei, Yang; He, Jinsong; Cui, Bing; Widhopf, George F.; Yu, Jian; et al. (Proceedings of the National Academy of Sciences - PNAS, 2019)
Keywords: Adenosine Triphosphatases - metabolism; Animals; Antibodies, Monoclonal; Antineoplastic Agents - pharmacology; B-cell lymphoma; Bearing; Biological Sciences; Breast - drug effects; Breast - metabolism; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Cancer; Cell Line, Tumor; Cell self-renewal; Chemotherapy; Drug Resistance, Neoplasm - drug effects; Female; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genes; Guanine nucleotide-binding protein; Heterografts; Homology; Humans; Immunoglobulins; Lymphoma; Metastases; Mice; Monoclonal antibodies; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; NIH 3T3 Cells; Nuclear Proteins - metabolism; Paclitaxel; Paclitaxel - pharmacology; Patients; PNAS Plus; Polycomb Repressive Complex 1 - metabolism; Protein-Serine-Threonine Kinases - metabolism; RAG2 protein; Receptor Tyrosine Kinase-like Orphan Receptors - metabolism; Spheroids; Stem cell transplantation; Stem cells; Transcription activation; Transcription Factors - metabolism; Tumors; Tyrosine; Xenografts; Xenotransplantation; Yes-associated protein; ROR1-signaling; cirmtuzumab; ROR1; chemotherapy; breast-cancer stem cells