A self-assembled Ru–Pt metallacage as a lysosome-targeting photosensitizer for 2-photon photodynamic therapy

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 41; pp. 20296 - 20302
• Main Authors: Zhou, Zhixuan, Liu, Jiangping, Huang, Juanjuan, Rees, Thomas W., Wang, Yiliang, Wang, Heng, Li, Xiaopeng, Chao, Hui, Stang, Peter J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 08.10.2019
• Subjects: A549 Cells; Absorption cross sections; Animals; Biological properties; Block copolymers; Cytotoxicity; Drug Development; Humans; I.R. radiation; In vivo methods and tests; Infrared radiation; Internalization; Irradiation; Light irradiation; Localization; Lysosomes; Metal Nanoparticles; Mice; Nanoparticles; Neoplasms, Experimental - drug therapy; Organometallic compounds; Photochemotherapy - methods; Photodynamic therapy; Photon absorption; Photons; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Physical Sciences; Platinum Compounds; Reactive oxygen species; Ruthenium; Ruthenium Compounds; Self-assembly; Spheroids; Tumor cells; Tumors; self-assembly; lysosome; photodynamic therapy; 2-photon absorption; coordination

Photodynamic therapy (PDT) is a treatment procedure that relies on cytotoxic reactive oxygen species (ROS) generated by the light activation of a photosensitizer. The photophysical and biological properties of photosensitizers are vital for the therapeutic outcome of PDT. In this work a 2D rhomboida...