Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume

• Published in: Pharmaceutical research Vol. 35; no. 10; pp. 194 - 12
• Main Authors: Farkas, Dale, Hindle, Michael, Longest, P. Worth
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2018; Springer; Springer Nature B.V
• Subjects: Administration, Inhalation; Aerosols; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Chemistry, Pharmaceutical; Computer simulation; Dry Powder Inhalers - instrumentation; Equipment Design; Inhalation Spacers; Inhalers; Lung - anatomy & histology; Lungs; Medical Law; Medical materials; Nasal Sprays; Nose; Nose - anatomy & histology; Oxygen - chemistry; Particle Size; Pharmacology/Toxicology; Pharmacy; Powder; Powders - chemistry; Research Paper; Respiration; Respiratory therapy; low flow oxygen; nasal cannula aerosol; pharmaceutical aerosol; inline DPI; low flow nasal cannula; Dry powder inhaler (DPI)
• DOI: 10.1007/s11095-018-2473-7
• ISSN: 0724-8741

Purpose To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy. Methods A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an in vitro nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered. Results For the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53–55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs. Conclusions The optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface.