Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume
Purpose To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy. Methods A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tu...
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Published in | Pharmaceutical research Vol. 35; no. 10; pp. 194 - 12 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.10.2018
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Abstract | Purpose
To demonstrate efficient aerosol delivery through an
in vitro
nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy.
Methods
A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an
in vitro
nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered.
Results
For the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53–55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs.
Conclusions
The optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface. |
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AbstractList | Purpose
To demonstrate efficient aerosol delivery through an
in vitro
nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy.
Methods
A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an
in vitro
nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered.
Results
For the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53–55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs.
Conclusions
The optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface. PURPOSETo demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy. METHODSA previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an in vitro nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered. RESULTSFor the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53-55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs. CONCLUSIONSThe optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface. To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy. A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an in vitro nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered. For the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53-55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs. The optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface. Purpose To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy. Methods A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an in vitro nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered. Results For the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53-55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs. Conclusions The optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface. |
ArticleNumber | 194 |
Audience | Academic |
Author | Farkas, Dale Longest, P. Worth Hindle, Michael |
AuthorAffiliation | 1 Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA 2 Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA |
AuthorAffiliation_xml | – name: 2 Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA – name: 1 Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA |
Author_xml | – sequence: 1 givenname: Dale surname: Farkas fullname: Farkas, Dale organization: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University – sequence: 2 givenname: Michael surname: Hindle fullname: Hindle, Michael organization: Department of Pharmaceutics, Virginia Commonwealth University Richmond – sequence: 3 givenname: P. Worth surname: Longest fullname: Longest, P. Worth email: pwlongest@vcu.edu organization: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Department of Pharmaceutics, Virginia Commonwealth University Richmond |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30132207$$D View this record in MEDLINE/PubMed |
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Keywords | low flow oxygen nasal cannula aerosol pharmaceutical aerosol inline DPI low flow nasal cannula Dry powder inhaler (DPI) |
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contributor: fullname: T Okuda – ident: 2473_CR19 – volume: 19 start-page: 301 year: 2006 ident: 2473_CR29 publication-title: J Aerosol Med. doi: 10.1089/jam.2006.19.301 contributor: fullname: JD Schroeter |
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Snippet | Purpose
To demonstrate efficient aerosol delivery through an
in vitro
nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV)... To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied... Purpose To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV)... PurposeTo demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV)... PURPOSETo demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV)... |
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SubjectTerms | Administration, Inhalation Aerosols Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical Computer simulation Dry Powder Inhalers - instrumentation Equipment Design Inhalation Spacers Inhalers Lung - anatomy & histology Lungs Medical Law Medical materials Nasal Sprays Nose Nose - anatomy & histology Oxygen - chemistry Particle Size Pharmacology/Toxicology Pharmacy Powder Powders - chemistry Research Paper Respiration Respiratory therapy |
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Title | Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume |
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