Targeting a ceramide double bond improves insulin resistance and hepatic steatosis - Chaurasia, Bhagirath; Tippetts, Trevor S.; Monibas, Rafael Mayoral; Liu, Jinqi; Li, Ying; Wang, Liping; Wilkerson, Joseph L.; Sweeney, C. Rufus; Pereira, Renato Felipe; Sumida, Doris Hissako; Maschek, J. Alan; Cox, James E.; et al. (Science (American Association for the Advancement of Science), 2019)
Keywords: Ablation; Adipose tissue; Animals; Backbone; Cardiovascular diseases; Ceramide; Ceramides - chemistry; Ceramides - genetics; Ceramides - metabolism; Coronary artery disease; Desaturase; Diabetes mellitus; Diet; Diet, High-Fat - adverse effects; Disease resistance; Disorders; Enzymes; Fat metabolism; Fatty liver; Fatty Liver - genetics; Fatty Liver - metabolism; Gene Deletion; Genetic engineering; Glucose; Glucose metabolism; Heart diseases; High fat diet; Inserts; Insulin; Insulin resistance; Insulin Resistance - genetics; Leptin; Leptin - deficiency; Lipid metabolism; Lipids; Liver; Liver diseases; Membrane Proteins - genetics; Metabolic disorders; Metabolic syndrome; Metabolism; Mice; Mice, Mutant Strains; Nutrient deficiency; Oxidoreductases - genetics; Sphingolipids; Sphingolipids - chemistry; Sphingolipids - metabolism; Steatosis