A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 50; pp. 1 - 11
• Main Authors: Liu, Xueqiao, Luongo, Cindy, Matsuokaa, Yumiko, Park, Hong-Su, Santos, Celia, Yang, Lijuan, Moore, Ian N., Afroz, Sharmin, Johnson, Reed F., Lafont, Bernard A. P., Martens, Craig, Best, Sonja M., Munster, Vincent J., Hollý, Jaroslav, Yewdell, Jonathan W., Le Nouën, Cyril, Munir, Shirin, Buchholz, Ursula J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.12.2021
• Subjects: Administration, Intranasal; Animals; Antibodies; Antibodies, Viral - blood; Antigens; Biological Sciences; Children; Coronaviruses; COVID-19; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - genetics; COVID-19 Vaccines - immunology; Cricetinae; Genetic Vectors; Hamsters; Immunization; Immunoglobulin A; Immunoglobulin G; Infants; Lungs; Neutralization; Neutralizing; Parainfluenza; Parainfluenza Virus 3, Bovine - genetics; Parainfluenza Virus 3, Human - genetics; Protein folding; Proteins; Replication; Respiratory tract; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Tissue culture; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Viruses; Weight loss; COVID-19; SARS-CoV-2; vaccine vector; intranasal immunization; parainfluenza virus vaccines

Single-dose vaccines with the ability to restrict SARS-CoV-2 replication in the respiratory tract are needed for all age groups, aiding efforts toward control of COVID-19. We developed a live intranasal vector vaccine for infants and children against COVID-19 based on replication-competent chimeric...