A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters - Liu, Xueqiao; Luongo, Cindy; Matsuokaa, Yumiko; Park, Hong-Su; Santos, Celia; Yang, Lijuan; Moore, Ian N.; Afroz, Sharmin; Johnson, Reed F.; Lafont, Bernard A. P.; Martens, Craig; Best, Sonja M.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2021)
Keywords: Administration, Intranasal; Animals; Antibodies; Antibodies, Viral - blood; Antigens; Biological Sciences; Children; Coronaviruses; COVID-19; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - genetics; COVID-19 Vaccines - immunology; Cricetinae; Genetic Vectors; Hamsters; Immunization; Immunoglobulin A; Immunoglobulin G; Infants; Lungs; Neutralization; Neutralizing; Parainfluenza; Parainfluenza Virus 3, Bovine - genetics; Parainfluenza Virus 3, Human - genetics; Protein folding; Proteins; Replication; Respiratory tract; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Tissue culture; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Viruses; Weight loss; COVID-19; SARS-CoV-2; vaccine vector; intranasal immunization; parainfluenza virus vaccines