GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma - Luo, Jie; Xia, Yuanzheng; Luo, Jun; Li, Junhe; Zhang, Chao; Zhang, Hao; Ma, Ting; Yang, Lei; Kong, Lingyi (Cancer letters, 2017)
Keywords: Activating Transcription Factor 4 - genetics; Activating Transcription Factor 4 - metabolism; Animals; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; ATF4; Bone cancer; Bone Neoplasms - drug therapy; Bone Neoplasms - genetics; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Bortezomib; Bortezomib - pharmacology; Cancer therapies; Cell death; Cell Death - drug effects; Cell Line, Tumor; Chemotherapy; CHOP; CHOP protein; Dose-Response Relationship, Drug; E1A-Associated p300 Protein - metabolism; Endoplasmic reticulum; Endoplasmic Reticulum Stress - drug effects; Event-related potentials; Gene Expression Regulation, Neoplastic; GRP78; Heat-Shock Proteins - antagonists & inhibitors; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Humans; Immunoglobulins; Laboratory animals; Male; Mice, Nude; Osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - genetics; Osteosarcoma - metabolism; Osteosarcoma - pathology; Plasmids; Polyacetylenes - pharmacology; Protein Binding; Protein biosynthesis; Protein Interaction Domains and Motifs; Protein Stability; Proteins; RNA Interference; Sarcoma; Signal transduction; Signal Transduction - drug effects; Time Factors; Transcription Factor CHOP - genetics; Transcription Factor CHOP - metabolism; Transfection; Tumorigenesis; Tumors; Ubiquitination; Xenograft Model Antitumor Assays; Xenografts; China; CFDA SE; HSPA5; OS; GRP78; BTZ; PERK; ER; Ubiquitination; CHX; Tg; Osteosarcoma; DDIT3; UPR; EdU; IRE1; ROS; CHOP; ATF4