Functional Comparison of SCARB2 and PSGL1 as Receptors for Enterovirus 71

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 87; no. 6; pp. 3335 - 3347
Main Authors Yamayoshi, Seiya, Ohka, Seii, Fujii, Ken, Koike, Satoshi
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.03.2013
Subjects
Animals
Cell Line
Enterovirus
Enterovirus A, Human - physiology
Humans
Lysosomal Membrane Proteins - metabolism
Membrane Glycoproteins - metabolism
Mice
Microscopy, Fluorescence
Receptors, Scavenger - metabolism
Receptors, Virus - metabolism
Virus Internalization
Virus Uncoating
Virus-Cell Interactions
Online AccessGet full text

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Human scavenger receptor class B, member 2 (SCARB2), and P-selectin glycoprotein ligand-1 (PSGL1) have been identified to be the cellular receptors for enterovirus 71 (EV71). We compared the EV71 infection efficiencies of mouse L cells that expressed SCARB2 (L-SCARB2) and PSGL1 (L-PSGL1) and the abilities of SCARB2 and PSGL1 to bind to the virus. L-SCARB2 cells bound a reduced amount of EV71 compared to L-PSGL1 cells. However, EV71 could infect L-SCARB2 cells more efficiently than L-PSGL1 cells. The results suggested that the difference in the binding capacities of the two receptors was not the sole determinant of the infection efficiency and that SCARB2 plays an essential role after attaching to virions. Therefore, we examined the viral entry into L-SCARB2 cells and L-PSGL1 cells by immunofluorescence microscopy. In both cells, we detected internalized EV71 virions that colocalized with an early endosome marker. We then performed a sucrose density gradient centrifugation analysis to evaluate viral uncoating. After incubating the EV71 virion with L-SCARB2 cells or soluble SCARB2 under acidic conditions below pH 6.0, we observed that part of the native virion was converted into an empty capsid that lacked both genomic RNA and VP4 capsid proteins. The results suggested that the uncoating of EV71 requires both SCARB2 and an acidic environment and occurs after the internalization of the virus-receptor complex into endosomes. However, the empty capsid formation was not observed after incubation with L-PSGL1 cells or soluble PSGL1 under any of the tested pH conditions. These results indicated that SCARB2 is capable of viral binding, viral internalization, and viral uncoating and that the low infection efficiency of L-PSGL1 cells is due to the inability of PSGL1 to induce viral uncoating. The characterization of SCARB2 as an uncoating receptor greatly contributes to the understanding of the early steps of EV71 infection.
Human scavenger receptor class B, member 2 (SCARB2), and P-selectin glycoprotein ligand-1 (PSGL1) have been identified to be the cellular receptors for enterovirus 71 (EV71). We compared the EV71 infection efficiencies of mouse L cells that expressed SCARB2 (L-SCARB2) and PSGL1 (L-PSGL1) and the abilities of SCARB2 and PSGL1 to bind to the virus. L-SCARB2 cells bound a reduced amount of EV71 compared to L-PSGL1 cells. However, EV71 could infect L-SCARB2 cells more efficiently than L-PSGL1 cells. The results suggested that the difference in the binding capacities of the two receptors was not the sole determinant of the infection efficiency and that SCARB2 plays an essential role after attaching to virions. Therefore, we examined the viral entry into L-SCARB2 cells and L-PSGL1 cells by immunofluorescence microscopy. In both cells, we detected internalized EV71 virions that colocalized with an early endosome marker. We then performed a sucrose density gradient centrifugation analysis to evaluate viral uncoating. After incubating the EV71 virion with L-SCARB2 cells or soluble SCARB2 under acidic conditions below pH 6.0, we observed that part of the native virion was converted into an empty capsid that lacked both genomic RNA and VP4 capsid proteins. The results suggested that the uncoating of EV71 requires both SCARB2 and an acidic environment and occurs after the internalization of the virus-receptor complex into endosomes. However, the empty capsid formation was not observed after incubation with L-PSGL1 cells or soluble PSGL1 under any of the tested pH conditions. These results indicated that SCARB2 is capable of viral binding, viral internalization, and viral uncoating and that the low infection efficiency of L-PSGL1 cells is due to the inability of PSGL1 to induce viral uncoating. The characterization of SCARB2 as an uncoating receptor greatly contributes to the understanding of the early steps of EV71 infection.Human scavenger receptor class B, member 2 (SCARB2), and P-selectin glycoprotein ligand-1 (PSGL1) have been identified to be the cellular receptors for enterovirus 71 (EV71). We compared the EV71 infection efficiencies of mouse L cells that expressed SCARB2 (L-SCARB2) and PSGL1 (L-PSGL1) and the abilities of SCARB2 and PSGL1 to bind to the virus. L-SCARB2 cells bound a reduced amount of EV71 compared to L-PSGL1 cells. However, EV71 could infect L-SCARB2 cells more efficiently than L-PSGL1 cells. The results suggested that the difference in the binding capacities of the two receptors was not the sole determinant of the infection efficiency and that SCARB2 plays an essential role after attaching to virions. Therefore, we examined the viral entry into L-SCARB2 cells and L-PSGL1 cells by immunofluorescence microscopy. In both cells, we detected internalized EV71 virions that colocalized with an early endosome marker. We then performed a sucrose density gradient centrifugation analysis to evaluate viral uncoating. After incubating the EV71 virion with L-SCARB2 cells or soluble SCARB2 under acidic conditions below pH 6.0, we observed that part of the native virion was converted into an empty capsid that lacked both genomic RNA and VP4 capsid proteins. The results suggested that the uncoating of EV71 requires both SCARB2 and an acidic environment and occurs after the internalization of the virus-receptor complex into endosomes. However, the empty capsid formation was not observed after incubation with L-PSGL1 cells or soluble PSGL1 under any of the tested pH conditions. These results indicated that SCARB2 is capable of viral binding, viral internalization, and viral uncoating and that the low infection efficiency of L-PSGL1 cells is due to the inability of PSGL1 to induce viral uncoating. The characterization of SCARB2 as an uncoating receptor greatly contributes to the understanding of the early steps of EV71 infection.
Author Satoshi Koike
Ken Fujii
Seiya Yamayoshi
Seii Ohka
Author_xml – sequence: 1
  givenname: Seiya
  surname: Yamayoshi
  fullname: Yamayoshi, Seiya
  organization: Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
– sequence: 2
  givenname: Seii
  surname: Ohka
  fullname: Ohka, Seii
  organization: Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
– sequence: 3
  givenname: Ken
  surname: Fujii
  fullname: Fujii, Ken
  organization: Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
– sequence: 4
  givenname: Satoshi
  surname: Koike
  fullname: Koike, Satoshi
  organization: Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23302872$$D View this record in MEDLINE/PubMed
BookMark eNqNkUFrFDEYhoNU7LZ68yzx5sGpyZfMJHMR6tLWlQWlVfH2kclkuimzyZrMbOm_d9ZtRQXBUw553peH7z0iByEGR8hzzk44B_3mw9fFCQOmWMHhEZlxVuuiLLk8IDPGAIpS6G-H5CjnG8a4lJV8Qg5BCAZawYwszsdgBx-D6ek8rjcm-RwDjR29mp9evgNqQks_XV0sOTWZXjrrNkNMmXYx0bMwuBS3Po2ZKv6UPO5Mn92z-_eYfDk_-zx_Xyw_Xizmp8vClqweCmlUC8qAbQR3VdtJycFC1-raCSt1VbZQikYKp1RTqykCtXC1gqaCqtKgxDF5u-_djM3atdaFIZkeN8mvTbrDaDz--RP8Cq_jFkVZA5dsKnh1X5Di99HlAdc-W9f3Jrg4ZuQChGYVB_kfKJ-soNY7rRe_a_3yeTj1BMAesCnmnFyH1g9md_rJ0vfIGe72xGlP_Lkn8l3o9V-hh95_4C_3-Mpfr259cmjyGm-2HrXCCoUQpfgBoJ2pFA
CitedBy_id crossref_primary_10_1016_j_dci_2021_104202
crossref_primary_10_1186_s12929_019_0574_1
crossref_primary_10_1038_ncomms13150
crossref_primary_10_1038_s41579_018_0005_4
crossref_primary_10_1371_journal_ppat_1008428
crossref_primary_10_1155_2014_878139
crossref_primary_10_22144_ctu_jvn_2022_091
crossref_primary_10_1073_pnas_1803347115
crossref_primary_10_3390_v17020181
crossref_primary_10_1007_s00705_021_04991_6
crossref_primary_10_1186_1743_422X_11_47
crossref_primary_10_1016_j_vaccine_2016_04_029
crossref_primary_10_1186_1423_0127_21_18
crossref_primary_10_1002_2211_5463_12197
crossref_primary_10_1128_jvi_02042_21
crossref_primary_10_1186_1423_0127_21_14
crossref_primary_10_3390_v13081661
crossref_primary_10_1007_s13238_014_0087_3
crossref_primary_10_1080_22221751_2020_1767512
crossref_primary_10_1186_s12985_021_01605_0
crossref_primary_10_1128_jvi_00542_21
crossref_primary_10_1016_j_ajpath_2013_11_009
crossref_primary_10_1038_s41598_018_25091_7
crossref_primary_10_1016_j_virol_2020_12_021
crossref_primary_10_1038_emi_2014_49
crossref_primary_10_1128_JVI_02251_17
crossref_primary_10_1038_nri3515
crossref_primary_10_1128_JVI_00681_18
crossref_primary_10_1128_JVI_01330_17
crossref_primary_10_1128_jvi_01655_24
crossref_primary_10_1111_iji_12134
crossref_primary_10_1016_j_bpj_2017_12_021
crossref_primary_10_1038_emi_2014_60
crossref_primary_10_1371_journal_pone_0111496
crossref_primary_10_1016_j_jviromet_2015_08_007
crossref_primary_10_3390_v11050460
crossref_primary_10_1007_s00018_022_04300_7
crossref_primary_10_1128_JVI_03519_12
crossref_primary_10_1002_elps_202300150
crossref_primary_10_1038_s41467_023_43029_0
crossref_primary_10_1371_journal_ppat_1003511
crossref_primary_10_1073_pnas_1217563110
crossref_primary_10_1128_mSphere_01048_20
crossref_primary_10_1016_j_antiviral_2021_105091
crossref_primary_10_4049_jimmunol_2300407
crossref_primary_10_1017_S0950268818000468
crossref_primary_10_1186_s12929_019_0540_y
crossref_primary_10_1186_s12879_017_2228_9
crossref_primary_10_1007_s00705_022_05606_4
crossref_primary_10_1128_JVI_03029_13
crossref_primary_10_1111_imm_13629
crossref_primary_10_1038_s41467_017_00736_9
crossref_primary_10_3390_molecules26216576
crossref_primary_10_1186_s12985_021_01557_5
crossref_primary_10_3390_v12080883
crossref_primary_10_1186_1743_422X_10_250
crossref_primary_10_1038_s41467_022_35575_w
crossref_primary_10_1586_eri_13_47
crossref_primary_10_1128_JVI_03498_14
crossref_primary_10_1128_JVI_01926_13
crossref_primary_10_1586_14787210_2014_895666
crossref_primary_10_1128_JVI_00205_15
crossref_primary_10_7554_eLife_98441
crossref_primary_10_1080_14787210_2021_1851194
crossref_primary_10_1007_s13238_017_0405_7
crossref_primary_10_1186_s12964_021_00812_0
crossref_primary_10_1128_JVI_00682_18
crossref_primary_10_1371_journal_ppat_1007760
crossref_primary_10_1128_JVI_00122_19
crossref_primary_10_1080_21645515_2015_1049780
crossref_primary_10_1371_journal_pone_0092719
crossref_primary_10_3390_v13020166
crossref_primary_10_1242_bio_059469
crossref_primary_10_1016_j_antiviral_2016_11_008
crossref_primary_10_1128_spectrum_02822_22
crossref_primary_10_1016_j_coviro_2021_10_006
crossref_primary_10_3390_v8020032
crossref_primary_10_1128_JVI_01921_19
crossref_primary_10_1093_nsr_nwv038
crossref_primary_10_1371_journal_ppat_1012022
crossref_primary_10_1080_22221751_2019_1618686
crossref_primary_10_1080_22221751_2021_1934558
crossref_primary_10_2222_jsv_74_153
crossref_primary_10_1016_j_coviro_2014_03_007
crossref_primary_10_1128_JVI_03826_13
crossref_primary_10_4049_jimmunol_1402312
crossref_primary_10_1007_s00705_023_05882_8
crossref_primary_10_1021_pr501199h
crossref_primary_10_1007_s13238_014_0092_6
crossref_primary_10_1186_s12929_020_0615_9
crossref_primary_10_1128_JVI_02189_15
crossref_primary_10_1371_journal_ppat_1011967
crossref_primary_10_3390_vaccines12091028
crossref_primary_10_1128_JVI_01515_21
crossref_primary_10_1038_s41564_018_0319_z
crossref_primary_10_1038_emi_2016_56
crossref_primary_10_2222_jsv_68_71
crossref_primary_10_1128_jvi_00561_22
crossref_primary_10_3389_fimmu_2020_561758
crossref_primary_10_1038_s41598_017_12388_2
crossref_primary_10_1016_j_biomaterials_2018_07_061
crossref_primary_10_1172_JCI99411
crossref_primary_10_1371_journal_pone_0206769
crossref_primary_10_1021_acs_jproteome_4c00536
Cites_doi 10.1056/NEJM199909233411301
10.1073/pnas.91.5.1839
10.1093/infdis/129.3.304
10.1099/vir.0.022418-0
10.1128/jvi.64.5.1934-1945.1990
10.1128/jvi.69.6.3873-3877.1995
10.1128/jvi.69.1.430-438.1995
10.1128/JCM.43.8.4139-4146.2005
10.1146/annurev.bi.58.070189.002533
10.1038/nri1351
10.1128/JVI.77.22.11985-11991.2003
10.1086/314032
10.1128/JVI.72.5.3578-3586.1998
10.1159/000148922
10.1002/jmv.2209
10.1126/science.1218713
10.1038/nsmb.2255
10.1016/0092-8674(93)90327-M
10.1016/j.jcv.2007.11.016
10.1128/jvi.71.12.9844-9848.1997
10.1016/S0140-6736(74)91684-5
10.1016/0092-8674(89)90689-2
10.1093/hmg/ddp523
10.1371/journal.ppat.1000620
10.1007/s00705-011-1198-2
10.1016/0092-8674(89)90688-0
10.1038/nm.1992
10.1126/science.275.5304.1320
10.1111/j.1574-6976.2002.tb00601.x
10.1128/JVI.00020-12
10.1371/journal.ppat.1001174
10.1016/j.cell.2007.10.018
10.1128/JVI.00531-10
10.1074/jbc.M110.168468
10.1073/pnas.86.13.4907
10.1182/blood.V88.8.3010.bloodjournal8883010
10.1002/j.1460-2075.1990.tb07520.x
10.1128/JVI.77.4.2500-2511.2003
10.1074/jbc.M111.301622
10.1073/pnas.94.7.3352
10.1016/S0140-6736(05)74253-7
10.1016/S1474-4422(08)70207-2
10.1016/S1386-6532(00)00067-6
10.1016/0092-8674(89)90690-9
10.1128/jvi.67.7.3989-3996.1993
10.1371/journal.ppat.1002473
10.1038/nm.1961
10.1128/jvi.64.10.4697-4702.1990
10.1086/376998
10.1016/S0092-8674(00)00138-0
10.1016/S0962-8924(03)00005-9
10.1128/jvi.68.6.3713-3723.1994
10.1371/journal.pone.0020005
10.1111/j.1348-0421.2002.tb02743.x
10.1016/j.chom.2008.02.001
10.1016/S0966-842X(02)02383-1
10.1128/JVI.79.1.655-660.2005
10.1016/j.cell.2005.10.035
10.1128/JCM.00563-09
10.1371/journal.pone.0030507
10.1128/JVI.02358-10
10.1086/345905
10.1099/vir.0.023374-0
ContentType Journal Article
Copyright Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology
Copyright_xml – notice: Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7U9
H94
5PM
DOI 10.1128/JVI.02070-12
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AIDS and Cancer Research Abstracts
Virology and AIDS Abstracts
DatabaseTitleList

MEDLINE - Academic
MEDLINE
AIDS and Cancer Research Abstracts
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 3347
ExternalDocumentID PMC3592140
23302872
10_1128_JVI_02070_12
jvi_87_6_3335
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-~X
0R~
18M
29L
2WC
39C
4.4
53G
5GY
5RE
5VS
85S
AAFWJ
AAGFI
AAYXX
ABPPZ
ACGFO
ACNCT
ADBBV
AENEX
AGVNZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
CITATION
CS3
DIK
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HYE
HZ~
IH2
KQ8
N9A
O9-
OK1
P2P
RHI
RNS
RPM
RSF
TR2
UPT
W2D
W8F
WH7
WOQ
YQT
~02
~KM
.55
.GJ
3O-
41~
6TJ
AAYJJ
ADXHL
AFFNX
AI.
C1A
CGR
CUY
CVF
D0S
ECM
EIF
MVM
NPM
OHT
VH1
X7M
Y6R
ZGI
ZXP
7X8
7U9
H94
5PM
ID FETCH-LOGICAL-c509t-4a7d27a2cb31e6df4412c2fd89e3c4865d253b43e77b97509293e972b62668273
ISSN 0022-538X
1098-5514
IngestDate Thu Aug 21 18:13:19 EDT 2025
Fri Jul 11 14:46:40 EDT 2025
Fri Jul 11 03:01:36 EDT 2025
Mon Jul 21 05:43:38 EDT 2025
Thu Apr 24 22:58:04 EDT 2025
Tue Jul 01 01:02:21 EDT 2025
Wed May 18 15:26:13 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c509t-4a7d27a2cb31e6df4412c2fd89e3c4865d253b43e77b97509293e972b62668273
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
OpenAccessLink https://jvi.asm.org/content/jvi/87/6/3335.full.pdf
PMID 23302872
PQID 1312662987
PQPubID 23479
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3592140
pubmed_primary_23302872
crossref_citationtrail_10_1128_JVI_02070_12
crossref_primary_10_1128_JVI_02070_12
proquest_miscellaneous_1312662987
highwire_asm_jvi_87_6_3335
proquest_miscellaneous_1323806124
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-03-01
PublicationDateYYYYMMDD 2013-03-01
PublicationDate_xml – month: 03
  year: 2013
  text: 2013-03-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 1752 N St., N.W., Washington, DC
PublicationTitle Journal of Virology
PublicationTitleAlternate J Virol
PublicationYear 2013
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References e_1_3_2_26_2
e_1_3_2_49_2
e_1_3_2_28_2
e_1_3_2_41_2
e_1_3_2_64_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_62_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_68_2
e_1_3_2_24_2
e_1_3_2_47_2
e_1_3_2_66_2
e_1_3_2_60_2
e_1_3_2_9_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_18_2
e_1_3_2_39_2
e_1_3_2_54_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_52_2
e_1_3_2_5_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_58_2
e_1_3_2_3_2
e_1_3_2_14_2
e_1_3_2_56_2
e_1_3_2_50_2
e_1_3_2_27_2
e_1_3_2_48_2
e_1_3_2_29_2
e_1_3_2_40_2
e_1_3_2_65_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_63_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_25_2
e_1_3_2_46_2
e_1_3_2_67_2
e_1_3_2_61_2
Tuthill TJ (e_1_3_2_35_2) 2010; 343
Bergelson JM (e_1_3_2_34_2) 2010
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
Reed LJ (e_1_3_2_59_2) 1938; 27
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_53_2
e_1_3_2_32_2
e_1_3_2_51_2
e_1_3_2_11_2
e_1_3_2_57_2
Racaniello V (e_1_3_2_2_2) 2007
e_1_3_2_4_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_55_2
References_xml – ident: e_1_3_2_13_2
  doi: 10.1056/NEJM199909233411301
– ident: e_1_3_2_42_2
  doi: 10.1073/pnas.91.5.1839
– ident: e_1_3_2_7_2
  doi: 10.1093/infdis/129.3.304
– ident: e_1_3_2_64_2
  doi: 10.1099/vir.0.022418-0
– ident: e_1_3_2_50_2
  doi: 10.1128/jvi.64.5.1934-1945.1990
– ident: e_1_3_2_45_2
  doi: 10.1128/jvi.69.6.3873-3877.1995
– volume: 343
  start-page: 43
  year: 2010
  ident: e_1_3_2_35_2
  article-title: Picornaviruses
  publication-title: Curr. Top. Microbiol. Immunol.
– ident: e_1_3_2_52_2
  doi: 10.1128/jvi.69.1.430-438.1995
– ident: e_1_3_2_57_2
  doi: 10.1128/JCM.43.8.4139-4146.2005
– ident: e_1_3_2_3_2
  doi: 10.1146/annurev.bi.58.070189.002533
– ident: e_1_3_2_31_2
  doi: 10.1038/nri1351
– ident: e_1_3_2_54_2
  doi: 10.1128/JVI.77.22.11985-11991.2003
– ident: e_1_3_2_12_2
  doi: 10.1086/314032
– ident: e_1_3_2_49_2
  doi: 10.1128/JVI.72.5.3578-3586.1998
– ident: e_1_3_2_9_2
  doi: 10.1159/000148922
– ident: e_1_3_2_55_2
  doi: 10.1002/jmv.2209
– start-page: 795
  volume-title: Fields virology
  year: 2007
  ident: e_1_3_2_2_2
– ident: e_1_3_2_5_2
  doi: 10.1126/science.1218713
– ident: e_1_3_2_4_2
  doi: 10.1038/nsmb.2255
– ident: e_1_3_2_28_2
  doi: 10.1016/0092-8674(93)90327-M
– ident: e_1_3_2_61_2
  doi: 10.1016/j.jcv.2007.11.016
– ident: e_1_3_2_46_2
  doi: 10.1128/jvi.71.12.9844-9848.1997
– ident: e_1_3_2_8_2
  doi: 10.1016/S0140-6736(74)91684-5
– ident: e_1_3_2_38_2
  doi: 10.1016/0092-8674(89)90689-2
– ident: e_1_3_2_22_2
  doi: 10.1093/hmg/ddp523
– ident: e_1_3_2_53_2
  doi: 10.1371/journal.ppat.1000620
– ident: e_1_3_2_33_2
  doi: 10.1007/s00705-011-1198-2
– ident: e_1_3_2_40_2
  doi: 10.1016/0092-8674(89)90688-0
– ident: e_1_3_2_18_2
  doi: 10.1038/nm.1992
– ident: e_1_3_2_43_2
  doi: 10.1126/science.275.5304.1320
– ident: e_1_3_2_10_2
  doi: 10.1111/j.1574-6976.2002.tb00601.x
– ident: e_1_3_2_23_2
  doi: 10.1128/JVI.00020-12
– ident: e_1_3_2_32_2
  doi: 10.1371/journal.ppat.1001174
– ident: e_1_3_2_21_2
  doi: 10.1016/j.cell.2007.10.018
– ident: e_1_3_2_66_2
  doi: 10.1128/JVI.00531-10
– ident: e_1_3_2_26_2
  doi: 10.1074/jbc.M110.168468
– ident: e_1_3_2_39_2
  doi: 10.1073/pnas.86.13.4907
– ident: e_1_3_2_29_2
  doi: 10.1182/blood.V88.8.3010.bloodjournal8883010
– ident: e_1_3_2_37_2
  doi: 10.1002/j.1460-2075.1990.tb07520.x
– ident: e_1_3_2_41_2
  doi: 10.1128/JVI.77.4.2500-2511.2003
– ident: e_1_3_2_25_2
  doi: 10.1074/jbc.M111.301622
– ident: e_1_3_2_44_2
  doi: 10.1073/pnas.94.7.3352
– ident: e_1_3_2_14_2
  doi: 10.1016/S0140-6736(05)74253-7
– ident: e_1_3_2_15_2
  doi: 10.1016/S1474-4422(08)70207-2
– ident: e_1_3_2_16_2
  doi: 10.1016/S1386-6532(00)00067-6
– ident: e_1_3_2_36_2
  doi: 10.1016/0092-8674(89)90690-9
– ident: e_1_3_2_56_2
  doi: 10.1128/jvi.67.7.3989-3996.1993
– ident: e_1_3_2_65_2
  doi: 10.1371/journal.ppat.1002473
– ident: e_1_3_2_19_2
  doi: 10.1038/nm.1961
– ident: e_1_3_2_62_2
  doi: 10.1128/jvi.64.10.4697-4702.1990
– ident: e_1_3_2_68_2
  doi: 10.1086/376998
– ident: e_1_3_2_30_2
  doi: 10.1016/S0092-8674(00)00138-0
– volume: 27
  start-page: 493
  year: 1938
  ident: e_1_3_2_59_2
  article-title: A simple method of estimating fifty per cent endpoints
  publication-title: Am. J. Hyg.
– ident: e_1_3_2_20_2
  doi: 10.1016/S0962-8924(03)00005-9
– ident: e_1_3_2_51_2
  doi: 10.1128/jvi.68.6.3713-3723.1994
– ident: e_1_3_2_63_2
  doi: 10.1371/journal.pone.0020005
– ident: e_1_3_2_11_2
  doi: 10.1111/j.1348-0421.2002.tb02743.x
– ident: e_1_3_2_58_2
  doi: 10.1016/j.chom.2008.02.001
– ident: e_1_3_2_6_2
  doi: 10.1016/S0966-842X(02)02383-1
– ident: e_1_3_2_47_2
  doi: 10.1128/JVI.79.1.655-660.2005
– ident: e_1_3_2_48_2
  doi: 10.1016/j.cell.2005.10.035
– ident: e_1_3_2_17_2
  doi: 10.1128/JCM.00563-09
– ident: e_1_3_2_27_2
  doi: 10.1371/journal.pone.0030507
– ident: e_1_3_2_24_2
  doi: 10.1128/JVI.02358-10
– ident: e_1_3_2_67_2
  doi: 10.1086/345905
– start-page: 73
  volume-title: The picornaviruses
  year: 2010
  ident: e_1_3_2_34_2
– ident: e_1_3_2_60_2
  doi: 10.1099/vir.0.023374-0
SSID ssj0014464
Score 2.4298878
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Human scavenger receptor class B, member 2 (SCARB2), and P-selectin glycoprotein ligand-1 (PSGL1) have been identified to be the cellular receptors for...
SourceID pubmedcentral
proquest
pubmed
crossref
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3335
SubjectTerms Animals
Cell Line
Enterovirus
Enterovirus A, Human - physiology
Humans
Lysosomal Membrane Proteins - metabolism
Membrane Glycoproteins - metabolism
Mice
Microscopy, Fluorescence
Receptors, Scavenger - metabolism
Receptors, Virus - metabolism
Virus Internalization
Virus Uncoating
Virus-Cell Interactions
Title Functional Comparison of SCARB2 and PSGL1 as Receptors for Enterovirus 71
URI http://jvi.asm.org/content/87/6/3335.abstract
https://www.ncbi.nlm.nih.gov/pubmed/23302872
https://www.proquest.com/docview/1312662987
https://www.proquest.com/docview/1323806124
https://pubmed.ncbi.nlm.nih.gov/PMC3592140
Volume 87
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgCIkXxDcZHzISPFUpje3EzuOYGOtAILENjScrcR0tgybV0k4qfz3nj6Tp1iHgJaoc17Hufrn8zvbdIfR6pHihzP5gDrYvZBkToch1ERJQNlhKUaTutMXnZP-YHZzEJ22Jex9dMs-H6tfGuJL_0Sq0gV5NlOw_aLYbFBrgN-gXrqBhuP6Vjvfgo-TX8lS_nuDgcHfn6zviIgEOP3yKTDUZMG16Zmvr2CzfRqD1RXm-aAauOskGimpi4Pqr7t-zabasG1sHGKxMuexs-pfTH5lvLDtILM7K0sf-dHa9Lv1pIHD2YaD-ooMpANGeuhpqZyhNHlLDtvqW1H86yytmkVKXk-SqvSYmBuHg23gItJWbcyL9biDt2dTqjlAKRMgV-bmUH7u9dRPdIuAqWLd6_LHbSQJ3l7UBD0S87T_KJIL2f15nJW2m6E1ex-XDsz02cnQP3fU6wjsOE_fRDV09QLddYdHlQzReIQOvkIHrAjtkYEAGtsjAWYM7ZGBABu4hA_PoETree3-0ux_6ohmhAu43h9eNTwjPiMpppJNJAXSXKFJMRKqpYiKJJySmOaOa8zw1dBH4nk45ycGzTQSQ2cdoq6or_RThnCY6KcC_JSPF4pwKVhCWUBiPkywiRYAGrdCk8hnlTWGTn9J6lkRIkLa00pYRCdCbrvfMZVK5pt92K3-ZNVN5dlFKwWUiDYgC9KrViAQ7aDa3skrXi0ZGMC-YaSr4n_oAQTWcngXoidNiN5UWCQHia_rtOpg87Ot3qvLU5mOncUoiNtq-dsxn6M7qJXqOtubnC_0CuOw8f2nB-hvY0Jmk
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+comparison+of+SCARB2+and+PSGL1+as+receptors+for+enterovirus+71&rft.jtitle=Journal+of+virology&rft.au=Yamayoshi%2C+Seiya&rft.au=Ohka%2C+Seii&rft.au=Fujii%2C+Ken&rft.au=Koike%2C+Satoshi&rft.date=2013-03-01&rft.eissn=1098-5514&rft.volume=87&rft.issue=6&rft.spage=3335&rft_id=info:doi/10.1128%2FJVI.02070-12&rft_id=info%3Apmid%2F23302872&rft.externalDocID=23302872
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon