Eimeria maxima recombinant Gam82 gametocyte antigen vaccine protects against coccidiosis and augments humoral and cell-mediated immunity
Abstract Intestinal infection with Eimeria , the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous parasite, while cross-protection against heterologous species is poor. As a first step toward the development of a broad specificity Eime...
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| Published in | Vaccine Vol. 28; no. 17; pp. 2980 - 2985 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Kidlington
Elsevier Ltd
09.04.2010
Elsevier Elsevier Limited |
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| Abstract | Abstract Intestinal infection with Eimeria , the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous parasite, while cross-protection against heterologous species is poor. As a first step toward the development of a broad specificity Eimeria vaccine, this study was designed to assess a purified recombinant protein from Eimeria maxima gametocytes (Gam82) in stimulating immunity against experimental infection with live parasites. Following Gam82 intramuscular immunization and oral parasite challenge, body weight gain, fecal oocyst output, lesion scores, serum antibody response, and cytokine production were assessed to evaluate vaccination efficacy. Animals vaccinated with Gam82 and challenged with E. maxima showed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals. Gam82 vaccination also stimulated the production of antigen-specific serum antibodies and induced greater levels of IL-2 and IL-15 mRNAs compared with non-vaccinated controls. These results demonstrate that the Gam82 recombinant protein protects against E. maxima and augments humoral and cell-mediated immunity. |
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| AbstractList | Intestinal infection with Eimeria, the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous parasite, while cross-protection against heterologous species is poor. As a first step toward the development of a broad specificity Eimeria vaccine, this study was designed to assess a purified recombinant protein from Eimeria maxima gametocytes (Gam82) in stimulating immunity against experimental infection with live parasites. Following Gam82 intramuscular immunization and oral parasite challenge, body weight gain, fecal oocyst output, lesion scores, serum antibody response, and cytokine production were assessed to evaluate vaccination efficacy. Animals vaccinated with Gam82 and challenged with E. maxima showed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals. Gam82 vaccination also stimulated the production of antigen-specific serum antibodies and induced greater levels of IL-2 and IL-15 mRNAs compared with non-vaccinated controls. These results demonstrate that the Gam82 recombinant protein protects against E. maxima and augments humoral and cell-mediated immunity. Intestinal infection with Eimeria, the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous parasite, while cross-protection against heterologous species is poor. As a first step toward the development of a broad specificity Eimeria vaccine, this study was designed to assess a purified recombinant protein from Eimeria maxima gametocytes (Gam82) in stimulating immunity against experimental infection with live parasites. Following Gam82 intramuscular immunization and oral parasite challenge, body weight gain, fecal oocyst output, lesion scores, serum antibody response, and cytokine production were assessed to evaluate vaccination efficacy. Animals vaccinated with Gam82 and challenged with E. maxima showed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals. Gam82 vaccination also stimulated the production of antigen-specific serum antibodies and induced greater levels of IL-2 and IL-15 mRNAs compared with non-vaccinated controls. These results demonstrate that the Gam82 recombinant protein protects against E. maxima and augments humoral and cell-mediated immunity. Intestinal infection withEimeria, the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous parasite, while cross-protection against heterologous species is poor. As a first step toward the development of a broad specificityEimeriavaccine, this study was designed to assess a purified recombinant protein fromEimeria maximagametocytes (Gam82) in stimulating immunity against experimental infection with live parasites. Following Gam82 intramuscular immunization and oral parasite challenge, body weight gain, fecal oocyst output, lesion scores, serum antibody response, and cytokine production were assessed to evaluate vaccination efficacy. Animals vaccinated with Gam82 and challenged withE. maximashowed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals. Gam82 vaccination also stimulated the production of antigen-specific serum antibodies and induced greater levels of IL-2 and IL-15 mRNAs compared with non-vaccinated controls. These results demonstrate that the Gam82 recombinant protein protects againstE. maximaand augments humoral and cell-mediated immunity. Abstract Intestinal infection with Eimeria , the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous parasite, while cross-protection against heterologous species is poor. As a first step toward the development of a broad specificity Eimeria vaccine, this study was designed to assess a purified recombinant protein from Eimeria maxima gametocytes (Gam82) in stimulating immunity against experimental infection with live parasites. Following Gam82 intramuscular immunization and oral parasite challenge, body weight gain, fecal oocyst output, lesion scores, serum antibody response, and cytokine production were assessed to evaluate vaccination efficacy. Animals vaccinated with Gam82 and challenged with E. maxima showed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals. Gam82 vaccination also stimulated the production of antigen-specific serum antibodies and induced greater levels of IL-2 and IL-15 mRNAs compared with non-vaccinated controls. These results demonstrate that the Gam82 recombinant protein protects against E. maxima and augments humoral and cell-mediated immunity. |
| Author | Srinivasan, V.A Subramanian, B. Mohana Lee, Sung Hyen Lillehoj, Hyun S Sriraman, R Lee, Kyung Woo Cha, Sung-Rok Lillehoj, Erik P Jang, Seung I Park, Myeong Seon |
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| Copyright | 2010 2015 INIST-CNRS Published by Elsevier Ltd. Copyright Elsevier Limited Apr 9, 2010 |
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| Keywords | Coccidiosis E. maxima Gam82 Protozoa Apicomplexa Protozoal disease Cellular immunity Vaccine Parasitosis Infection Eimeria maxima Recombinant protein Humoral immunity |
| Language | English |
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| Snippet | Abstract Intestinal infection with Eimeria , the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the... Intestinal infection with Eimeria, the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous... Intestinal infection with Eimeria, the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous... Intestinal infection withEimeria, the etiologic agent of avian coccidiosis, stimulates protective immunity to subsequent colonization by the homologous... |
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| SubjectTerms | Allergy and Immunology Animals Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Antibody response Antigens, Protozoan - administration & dosage Antigens, Protozoan - immunology Applied microbiology Biological and medical sciences Body Weight Cell growth Chickens Coccidiosis Coccidiosis - immunology Coccidiosis - pathology Coccidiosis - prevention & control Coccidiosis - veterinary Cytokines Cytokines - secretion E. maxima Eimeria Eimeria - immunology Fundamental and applied biological sciences. Psychology Gam82 Human protozoal diseases Immunity, Cellular Immunization Infectious diseases Injections, Intramuscular Intestines - pathology Medical sciences Microbiology Parasite Egg Count Parasites Parasitic diseases Poultry Poultry Diseases - immunology Poultry Diseases - pathology Poultry Diseases - prevention & control Protected species Proteins Protozoal diseases Protozoan Vaccines - administration & dosage Protozoan Vaccines - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
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| Title | Eimeria maxima recombinant Gam82 gametocyte antigen vaccine protects against coccidiosis and augments humoral and cell-mediated immunity |
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