Alpha and alpha-beta phase synchronization mediate the recruitment of the visuospatial attention network through the Superior Longitudinal Fasciculus

• Published in: NeuroImage (Orlando, Fla.) Vol. 188; pp. 722 - 732
• Main Authors: D'Andrea, Antea, Chella, Federico, Marshall, Tom R., Pizzella, Vittorio, Romani, Gian Luca, Jensen, Ole, Marzetti, Laura
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2019; Elsevier Limited
• Subjects: Adult; Alpha Rhythm - physiology; Asymmetry; Attention - physiology; Beta Rhythm - physiology; Brain research; Cortical Synchronization - physiology; Electroencephalography; Female; Hemispheric laterality; Humans; Magnetoencephalography; Magnetoencephalography - methods; Male; Nerve Net - diagnostic imaging; Nerve Net - physiology; Neural Pathways - physiology; Oscillations; Space Perception - physiology; Synchronization; Visual Perception - physiology; White Matter - physiology; Young Adult
• DOI: 10.1016/j.neuroimage.2018.12.056
• ISSN: 1053-8119; 1095-9572

It is well known that attentional selection of relevant information relies on local synchronization of alpha band neuronal oscillations in visual cortices for inhibition of distracting inputs. Additionally, evidence for long-range coupling of neuronal oscillations between visual cortices and regions engaged in the anticipation of upcoming stimuli has been more recently provided. Nevertheless, on the one hand the relation between long-range functional coupling and anatomical connections is still to be assessed, and, on the other hand, the specific role of the alpha and beta frequency bands in the different processes underlying visuo-spatial attention still needs further clarification. We address these questions using measures of linear (frequency-specific) and nonlinear (cross-frequency) phase-synchronization in a cohort of 28 healthy subjects using magnetoencephalography. We show that alpha band phase-synchronization is modulated by the orienting of attention according to a parieto-occipital top-down mechanism reflecting behavior, and its hemispheric asymmetry is predicted by volume's asymmetry of specific tracts of the Superior-Longitudinal-Fasciculus. We also show that a network comprising parietal regions and the right putative Frontal-Eye-Field, but not the left, is recruited in the deployment of spatial attention through an alpha-beta cross-frequency coupling. Overall, we demonstrate that the visuospatial attention network features subsystems indexed by characteristic spectral fingerprints, playing different functional roles in the anticipation of upcoming stimuli and with diverse relation to fiber tracts. •Orienting visuo-spatial attention modulates parieto-occipital alpha synchronization.•Hemispheric asymmetry of alpha connectivity is predicted by asymmetry of SLF.•Hemispheric asymmetry of alpha connectivity reflects subject's performance.•Alpha-beta cross-frequency coupling indexes attention deployment but not orienting.