Mitogen-activated Protein Kinase (MAPK)-regulated Interactions between Osterix and Runx2 Are Critical for the Transcriptional Osteogenic Program

• Published in: The Journal of biological chemistry Vol. 289; no. 39; pp. 27105 - 27117
• Main Authors: Artigas, Natalia, Ureña, Carlos, Rodríguez-Carballo, Edgardo, Rosa, José Luis, Ventura, Francesc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.09.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Core Binding Factor Alpha 1 Subunit - genetics; Core Binding Factor Alpha 1 Subunit - metabolism; Extracellular Signal-Regulated MAP Kinases - genetics; Extracellular Signal-Regulated MAP Kinases - metabolism; Gene Regulation; HEK293 Cells; Humans; MAP Kinase Signaling System - physiology; Mice; Osteogenesis - physiology; Sp7 Transcription Factor; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic - physiology; Transcription; Mitogen-activated Protein Kinase (MAPK); Osterix; Osteoblast; Cell Differentiation; Bone; p38 MAPK; Extracellular Signal-regulated Kinase (ERK); Runx2

The transcription factors Runx2 and Osx (Osterix) are required for osteoblast differentiation and bone formation. Runx2 expression occurs at early stages of osteochondroprogenitor determination, followed by Osx induction during osteoblast maturation. We demonstrate that coexpression of Osx and Runx2...