Enhanced isolation of SARS-CoV-2 by TMPRSS2- expressing cells
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2- expressing VeroE6 cell line is highly susceptible to...
Saved in:
| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 13; pp. 7001 - 7003 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
31.03.2020
|
| Series | Brief Report |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2- expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2. |
|---|---|
| AbstractList | A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2. A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2. |
| Author | Tahara, Maino Kuroda, Makoto Suzuki, Tadaki Sakata, Masafumi Kawase, Miyuki Katoh, Hiroshi Takeda, Makoto Ohmagari, Norio Nagata, Noriyo Kutsuna, Satoshi Nao, Naganori Kageyama, Tsutomu Matsuyama, Shutoku Saito, Shinji Shirato, Kazuya Takayama, Ikuyo Kato, Fumihiro Sekizuka, Tsuyoshi |
| Author_xml | – sequence: 1 givenname: Shutoku surname: Matsuyama fullname: Matsuyama, Shutoku – sequence: 2 givenname: Naganori surname: Nao fullname: Nao, Naganori – sequence: 3 givenname: Kazuya surname: Shirato fullname: Shirato, Kazuya – sequence: 4 givenname: Miyuki surname: Kawase fullname: Kawase, Miyuki – sequence: 5 givenname: Shinji surname: Saito fullname: Saito, Shinji – sequence: 6 givenname: Ikuyo surname: Takayama fullname: Takayama, Ikuyo – sequence: 7 givenname: Noriyo surname: Nagata fullname: Nagata, Noriyo – sequence: 8 givenname: Tsuyoshi surname: Sekizuka fullname: Sekizuka, Tsuyoshi – sequence: 9 givenname: Hiroshi surname: Katoh fullname: Katoh, Hiroshi – sequence: 10 givenname: Fumihiro surname: Kato fullname: Kato, Fumihiro – sequence: 11 givenname: Masafumi surname: Sakata fullname: Sakata, Masafumi – sequence: 12 givenname: Maino surname: Tahara fullname: Tahara, Maino – sequence: 13 givenname: Satoshi surname: Kutsuna fullname: Kutsuna, Satoshi – sequence: 14 givenname: Norio surname: Ohmagari fullname: Ohmagari, Norio – sequence: 15 givenname: Makoto surname: Kuroda fullname: Kuroda, Makoto – sequence: 16 givenname: Tadaki surname: Suzuki fullname: Suzuki, Tadaki – sequence: 17 givenname: Tsutomu surname: Kageyama fullname: Kageyama, Tsutomu – sequence: 18 givenname: Makoto surname: Takeda fullname: Takeda, Makoto |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32165541$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1vEzEUxC3UiqaFMyfQSly4bPv8bR9AqqJCkYpATeFqOV5v62hjp_YG0f8epykp9MDJkv2b8Zs3h2gvpugReoXhGIOkJ6toyzEBIFxpjOUzNMGgcSuYhj00qfeyVYywA3RYygIANFfwHB1QggXnDE_Q-7N4Y6PzXRNKGuwYUmxS38xOL2ftNP1oSTO_a66-fLuczUjb-F-r7EsJ8bpxfhjKC7Tf26H4lw_nEfr-8exqet5efP30eXp60ToOemwpcZQq3SsxF045qzshvJN8bgkoJQEU5Z3wFCyV2BLuZK-4sETgzmnGHD1CH7a-q_V86Tvn45jtYFY5LG2-M8kG8-9LDDfmOv00EteoFKrBuweDnG7XvoxmGcomgo0-rYshVErKKCWsom-foIu0zrHGq5SSTEkuaaXe_D3RbpQ_m63AyRZwOZWSfb9DMJhNd2bTnXnsrir4E4UL430jNVIY_qN7vdUtypjy7hsiNNEMc_ob3_Gkmg |
| CitedBy_id | crossref_primary_10_3389_fmicb_2022_967019 crossref_primary_10_1371_journal_ppat_1009233 crossref_primary_10_3390_v12091006 crossref_primary_10_3390_v14112577 crossref_primary_10_3390_pharmaceutics16101262 crossref_primary_10_1371_journal_ppat_1010464 crossref_primary_10_1080_07391102_2021_2024260 crossref_primary_10_1007_s11596_021_2470_7 crossref_primary_10_1016_j_jviromet_2020_113995 crossref_primary_10_1016_j_bbrc_2022_04_072 crossref_primary_10_1248_cpb_c22_00345 crossref_primary_10_1038_s41467_024_55272_0 crossref_primary_10_15252_emmm_202013191 crossref_primary_10_1016_j_mtbio_2022_100265 crossref_primary_10_1016_j_virol_2020_12_020 crossref_primary_10_1186_s40001_022_00927_1 crossref_primary_10_1080_17476348_2021_1823833 crossref_primary_10_1128_jvi_00416_24 crossref_primary_10_1128_jcm_00187_22 crossref_primary_10_1016_j_vaccine_2022_02_047 crossref_primary_10_3389_fphys_2020_00730 crossref_primary_10_1016_j_prp_2021_153565 crossref_primary_10_1038_s41598_021_89224_1 crossref_primary_10_3390_biomedicines10112710 crossref_primary_10_15252_embj_2020106267 crossref_primary_10_3389_fpubh_2021_591982 crossref_primary_10_1016_j_isci_2021_103144 crossref_primary_10_21307_PM_2020_59_3_15 crossref_primary_10_1016_j_bioorg_2020_104326 crossref_primary_10_3389_fphar_2022_804103 crossref_primary_10_1001_jama_2022_18550 crossref_primary_10_1172_jci_insight_153165 crossref_primary_10_1080_13102818_2020_1847683 crossref_primary_10_1371_journal_pbio_3002767 crossref_primary_10_17343_sdutfd_863761 crossref_primary_10_1186_s40246_023_00496_2 crossref_primary_10_3390_app13031522 crossref_primary_10_1093_infdis_jiaa437 crossref_primary_10_1128_spectrum_01181_21 crossref_primary_10_3390_vaccines10111962 crossref_primary_10_1007_s00018_020_03745_y crossref_primary_10_1021_acsinfecdis_0c00274 crossref_primary_10_3389_fimmu_2024_1440314 crossref_primary_10_1080_22221751_2021_1898291 crossref_primary_10_1016_j_isci_2021_103379 crossref_primary_10_1016_j_meegid_2021_104760 crossref_primary_10_1111_irv_13109 crossref_primary_10_1038_s41429_023_00623_0 crossref_primary_10_1021_acs_jmedchem_4c00053 crossref_primary_10_3389_fviro_2023_1137133 crossref_primary_10_2174_1381612828666220907105543 crossref_primary_10_1016_j_heliyon_2024_e25734 crossref_primary_10_3389_fmicb_2025_1546946 crossref_primary_10_1159_000512880 crossref_primary_10_3390_v14020366 crossref_primary_10_1038_s41551_021_00718_9 crossref_primary_10_1016_j_mehy_2020_110394 crossref_primary_10_1016_j_mehy_2020_110155 crossref_primary_10_1016_j_jim_2023_113440 crossref_primary_10_3389_fcimb_2020_00290 crossref_primary_10_1016_j_scitotenv_2020_141364 crossref_primary_10_1089_jir_2022_0029 crossref_primary_10_3390_biomedicines8110462 crossref_primary_10_1080_22221751_2023_2281356 crossref_primary_10_1016_j_jiph_2021_04_005 crossref_primary_10_1016_j_isci_2021_103120 crossref_primary_10_1128_JVI_00002_21 crossref_primary_10_1007_s11084_024_09648_3 crossref_primary_10_1038_s41467_021_27881_6 crossref_primary_10_1111_bcp_14540 crossref_primary_10_1016_j_matt_2021_04_005 crossref_primary_10_3390_vaccines11091469 crossref_primary_10_1007_s11224_022_01921_3 crossref_primary_10_1038_s41579_022_00822_w crossref_primary_10_7554_eLife_62522 crossref_primary_10_1038_s41392_024_01917_x crossref_primary_10_1038_s41541_024_00838_8 crossref_primary_10_1371_journal_pone_0266270 crossref_primary_10_2222_jsv_70_155 crossref_primary_10_1016_j_jiac_2024_08_020 crossref_primary_10_1080_10408363_2020_1776675 crossref_primary_10_3389_fmed_2021_836658 crossref_primary_10_1016_j_bbrep_2022_101379 crossref_primary_10_12688_aasopenres_13059_1 crossref_primary_10_3390_pathogens10091197 crossref_primary_10_3390_polym13020207 crossref_primary_10_4103_ijmm_IJMM_20_54 crossref_primary_10_1016_j_hjc_2020_05_004 crossref_primary_10_3390_v14051066 crossref_primary_10_1016_j_crchbi_2022_100023 crossref_primary_10_1371_journal_ppat_1009668 crossref_primary_10_3390_foods11142096 crossref_primary_10_1186_s12929_020_00703_5 crossref_primary_10_1016_j_isci_2022_105427 crossref_primary_10_1021_acsbiomaterials_0c01226 crossref_primary_10_3390_cimb43020053 crossref_primary_10_1128_AAC_01543_21 crossref_primary_10_1128_mBio_01598_21 crossref_primary_10_1016_j_antiviral_2024_106012 crossref_primary_10_1016_j_jviromet_2021_114084 crossref_primary_10_1186_s12301_020_00075_0 crossref_primary_10_3389_fmed_2021_793437 crossref_primary_10_3389_fcimb_2021_639177 crossref_primary_10_1038_s41598_022_08104_4 crossref_primary_10_1016_j_virol_2024_110068 crossref_primary_10_2208_jscejer_77_7_III_191 crossref_primary_10_3389_fnhum_2022_991382 crossref_primary_10_2139_ssrn_4166077 crossref_primary_10_3389_fphar_2021_576093 crossref_primary_10_1016_j_vaccine_2022_10_092 crossref_primary_10_1038_s41467_021_27097_8 crossref_primary_10_1007_s42247_021_00178_6 crossref_primary_10_1038_s41598_021_94095_7 crossref_primary_10_15252_embj_2021107821 crossref_primary_10_1038_s41596_023_00874_z crossref_primary_10_1016_j_jaci_2021_03_038 crossref_primary_10_1002_jmv_29094 crossref_primary_10_1016_j_jiac_2020_11_015 crossref_primary_10_1016_j_isci_2024_109597 crossref_primary_10_1080_22221751_2020_1830715 crossref_primary_10_1186_s12941_020_00384_w crossref_primary_10_30699_mmlj17_4_1_11 crossref_primary_10_1093_infdis_jiab337 crossref_primary_10_1136_bmjresp_2020_000830 crossref_primary_10_3389_fviro_2021_793320 crossref_primary_10_3390_ijms24108711 crossref_primary_10_1016_j_bios_2024_116617 crossref_primary_10_1371_journal_pone_0235106 crossref_primary_10_3390_v14020325 crossref_primary_10_1016_j_bbrc_2021_09_015 crossref_primary_10_3389_fgene_2021_581726 crossref_primary_10_1146_annurev_biophys_102620_080956 crossref_primary_10_1016_j_jhin_2024_11_005 crossref_primary_10_1016_j_isci_2024_109363 crossref_primary_10_1021_acs_chemrev_1c00965 crossref_primary_10_1016_j_jbc_2021_100346 crossref_primary_10_1016_j_xcrm_2021_100311 crossref_primary_10_1038_s41598_024_75338_9 crossref_primary_10_1371_journal_pbio_3001016 crossref_primary_10_1681_ASN_2020101537 crossref_primary_10_1016_j_str_2021_04_005 crossref_primary_10_1128_aac_00439_22 crossref_primary_10_1016_j_isci_2022_103830 crossref_primary_10_1007_s11224_022_01991_3 crossref_primary_10_1016_j_cmi_2022_05_020 crossref_primary_10_1016_j_jcyt_2021_08_003 crossref_primary_10_1016_j_drudis_2021_12_014 crossref_primary_10_3389_fphar_2020_01169 crossref_primary_10_1002_pros_24232 crossref_primary_10_3390_ijms23073711 crossref_primary_10_1038_s41467_023_38188_z crossref_primary_10_2139_ssrn_3879085 crossref_primary_10_1080_22221751_2020_1827985 crossref_primary_10_1111_nep_13814 crossref_primary_10_1002_rmv_2411 crossref_primary_10_1093_cid_ciac282 crossref_primary_10_1371_journal_ppat_1008536 crossref_primary_10_1002_adhm_202102089 crossref_primary_10_1038_s41586_022_04856_1 crossref_primary_10_3390_vaccines8030386 crossref_primary_10_1038_s41564_020_00841_4 crossref_primary_10_1093_jac_dkad027 crossref_primary_10_1016_j_ijid_2021_03_052 crossref_primary_10_1016_j_scr_2021_102207 crossref_primary_10_1007_s11055_021_01082_6 crossref_primary_10_1128_spectrum_03530_23 crossref_primary_10_3390_jcm11154474 crossref_primary_10_3390_s20154289 crossref_primary_10_1128_JCM_02257_20 crossref_primary_10_1038_s41467_023_42796_0 crossref_primary_10_1038_s41467_024_45274_3 crossref_primary_10_2139_ssrn_4123178 crossref_primary_10_1038_s42003_025_07827_0 crossref_primary_10_3390_v16091436 crossref_primary_10_1016_j_mayocp_2020_06_018 crossref_primary_10_1016_j_mcpro_2021_100103 crossref_primary_10_1111_ajt_16933 crossref_primary_10_3390_microorganisms13030507 crossref_primary_10_2807_1560_7917_ES_2020_25_25_2001122 crossref_primary_10_1016_j_jiph_2023_05_004 crossref_primary_10_3389_fcell_2021_714999 crossref_primary_10_1016_j_antiviral_2024_106026 crossref_primary_10_1186_s12929_021_00784_w crossref_primary_10_1016_j_stemcr_2020_11_009 crossref_primary_10_3390_v14091976 crossref_primary_10_3390_vaccines10101751 crossref_primary_10_1007_s00705_022_05545_0 crossref_primary_10_1093_ofid_ofaa648 crossref_primary_10_33611_trs_2021_023 crossref_primary_10_1371_journal_pbio_3001265 crossref_primary_10_1371_journal_pone_0261802 crossref_primary_10_3201_eid2609_201495 crossref_primary_10_1128_mBio_03192_20 crossref_primary_10_3389_fmed_2021_606755 crossref_primary_10_1126_sciadv_abo6783 crossref_primary_10_1002_rmv_2222 crossref_primary_10_1155_2021_8856018 crossref_primary_10_3390_v14010106 crossref_primary_10_1681_ASN_2020111546 crossref_primary_10_1016_j_genrep_2024_102039 crossref_primary_10_1111_bjh_19143 crossref_primary_10_3390_ijms25189977 crossref_primary_10_3389_fnins_2023_1117845 crossref_primary_10_4103_iju_IJU_346_20 crossref_primary_10_1093_infdis_jiac276 crossref_primary_10_1016_j_biopha_2020_111193 crossref_primary_10_18370_2309_4117_2020_54_8_21 crossref_primary_10_1002_lary_29132 crossref_primary_10_1038_s41419_022_04961_z crossref_primary_10_1038_s41467_023_37059_x crossref_primary_10_3390_v14071507 crossref_primary_10_1016_j_phrs_2020_104853 crossref_primary_10_1093_glycob_cwab032 crossref_primary_10_2139_ssrn_3900407 crossref_primary_10_3389_fmicb_2022_915202 crossref_primary_10_1155_2022_1806427 crossref_primary_10_1016_j_isci_2023_108147 crossref_primary_10_3390_pathogens12030480 crossref_primary_10_2139_ssrn_4150588 crossref_primary_10_1002_slct_202002420 crossref_primary_10_1128_JVI_00083_21 crossref_primary_10_1186_s12884_025_07205_y crossref_primary_10_55905_cuadv15n10_011 crossref_primary_10_1038_s41598_022_14552_9 crossref_primary_10_1099_acmi_0_000716_v3 crossref_primary_10_1080_22221751_2020_1756700 crossref_primary_10_1038_s41467_022_34655_1 crossref_primary_10_3390_vaccines10040614 crossref_primary_10_1021_acs_jcim_1c00384 crossref_primary_10_3390_v13050942 crossref_primary_10_3390_vaccines12050505 crossref_primary_10_1016_j_scitotenv_2022_158966 crossref_primary_10_1007_s00795_022_00326_9 crossref_primary_10_1371_journal_ppat_1010802 crossref_primary_10_1002_ddr_21709 crossref_primary_10_1001_jamapediatrics_2021_4897 crossref_primary_10_1016_j_ajpath_2021_05_009 crossref_primary_10_1016_j_cscee_2021_100105 crossref_primary_10_1016_j_envint_2022_107580 crossref_primary_10_1021_acs_analchem_2c04988 crossref_primary_10_1016_j_virol_2020_12_013 crossref_primary_10_1172_jci_insight_155944 crossref_primary_10_3390_cancers16020298 crossref_primary_10_1016_j_jiac_2021_09_006 crossref_primary_10_1016_j_virol_2020_12_008 crossref_primary_10_1007_s00347_020_01281_5 crossref_primary_10_1021_acsomega_1c03511 crossref_primary_10_1080_22221751_2022_2026739 crossref_primary_10_1016_j_mehy_2022_110966 crossref_primary_10_1002_jcp_30032 crossref_primary_10_1038_s41598_021_81451_w crossref_primary_10_1128_mbio_02737_24 crossref_primary_10_3389_fimmu_2020_01229 crossref_primary_10_3390_v13010029 crossref_primary_10_1073_pnas_2021579118 crossref_primary_10_3389_fimmu_2021_683800 crossref_primary_10_1007_s11845_021_02881_z crossref_primary_10_1007_s00204_020_02869_1 crossref_primary_10_1126_sciadv_adk4920 crossref_primary_10_1016_j_jviromet_2023_114812 crossref_primary_10_1016_j_dmpk_2024_101041 crossref_primary_10_1038_s41467_023_42717_1 crossref_primary_10_1038_s41598_021_01930_y crossref_primary_10_3390_pathogens11080922 crossref_primary_10_1016_j_chom_2021_06_006 crossref_primary_10_1016_j_chom_2021_06_008 crossref_primary_10_1016_j_envres_2021_111839 crossref_primary_10_1016_j_pharmthera_2021_108027 crossref_primary_10_1172_JCI146927 crossref_primary_10_3390_pathogens13010018 crossref_primary_10_3389_fmicb_2022_1093646 crossref_primary_10_3390_ph15060696 crossref_primary_10_2147_JIR_S298242 crossref_primary_10_2491_jjsth_34_449 crossref_primary_10_1002_jmv_70156 crossref_primary_10_1021_acsnano_0c03597 crossref_primary_10_1038_s41586_022_05482_7 crossref_primary_10_1038_s41598_023_28591_3 crossref_primary_10_3201_eid3008_231056 crossref_primary_10_1371_journal_pcbi_1008461 crossref_primary_10_1038_s41598_021_93231_7 crossref_primary_10_1038_s41586_022_04441_6 crossref_primary_10_1128_msphere_00411_22 crossref_primary_10_3390_ani12030378 crossref_primary_10_3390_v14061225 crossref_primary_10_1016_j_virol_2023_05_013 crossref_primary_10_1073_pnas_2407437121 crossref_primary_10_1128_spectrum_00456_23 crossref_primary_10_1093_ajcp_aqab087 crossref_primary_10_1016_j_celrep_2023_113580 crossref_primary_10_1016_j_jbc_2023_104763 crossref_primary_10_3390_v13081669 crossref_primary_10_1038_s41467_021_21118_2 crossref_primary_10_1371_journal_pbio_3001091 crossref_primary_10_1109_JSTSP_2021_3061251 crossref_primary_10_1016_j_vaccine_2023_08_076 crossref_primary_10_3390_vaccines8040584 crossref_primary_10_4103_ijo_IJO_639_20 crossref_primary_10_1038_s41575_021_00480_y crossref_primary_10_1016_j_intimp_2021_108086 crossref_primary_10_1038_s41467_022_33911_8 crossref_primary_10_3390_ijerph17186688 crossref_primary_10_1128_CMR_00162_20 crossref_primary_10_1007_s00705_021_05343_0 crossref_primary_10_15252_embr_202357137 crossref_primary_10_1016_j_celrep_2022_110829 crossref_primary_10_1097_ACI_0000000000000724 crossref_primary_10_3390_v16121936 crossref_primary_10_3389_fmicb_2022_781770 crossref_primary_10_1007_s00403_020_02156_0 crossref_primary_10_1073_pnas_2009799117 crossref_primary_10_1021_acsinfecdis_1c00017 crossref_primary_10_1080_07391102_2021_1891969 crossref_primary_10_3390_vaccines11030615 crossref_primary_10_1038_s41467_021_26910_8 crossref_primary_10_1080_07391102_2020_1767690 crossref_primary_10_1128_msphere_00812_23 crossref_primary_10_3389_fcimb_2022_841447 crossref_primary_10_1126_sciadv_abh3827 crossref_primary_10_1186_s12985_023_02152_6 crossref_primary_10_1016_j_chom_2024_01_001 crossref_primary_10_2478_s11756_020_00614_8 crossref_primary_10_1002_jcb_30528 crossref_primary_10_1074_jbc_RA120_014525 crossref_primary_10_1128_mbio_03331_24 crossref_primary_10_1016_j_celrep_2021_109305 crossref_primary_10_1146_annurev_pharmtox_121120_012309 crossref_primary_10_3390_v16081243 crossref_primary_10_1093_qjmed_hcaa296 crossref_primary_10_1016_j_jiac_2023_11_020 crossref_primary_10_1007_s00795_021_00309_2 crossref_primary_10_1111_1348_0421_12985 crossref_primary_10_1016_j_virol_2021_02_003 crossref_primary_10_3390_v13030384 crossref_primary_10_1038_s41577_020_0348_8 crossref_primary_10_1038_s41586_022_04474_x crossref_primary_10_1128_mBio_01833_20 crossref_primary_10_3390_v14071461 crossref_primary_10_1016_j_isci_2023_107208 crossref_primary_10_1128_mbio_00099_22 crossref_primary_10_1364_JOSAA_498859 crossref_primary_10_3389_fviro_2024_1353661 crossref_primary_10_3390_cells13211749 crossref_primary_10_1124_jpet_120_000123 crossref_primary_10_1016_j_antiviral_2023_105550 crossref_primary_10_3389_fimmu_2021_700926 crossref_primary_10_1016_j_isci_2021_102420 crossref_primary_10_3390_v13081459 crossref_primary_10_1007_s11033_021_06390_1 crossref_primary_10_20965_jdr_2023_p0027 crossref_primary_10_1128_AAC_00020_21 crossref_primary_10_1002_jev2_12269 crossref_primary_10_1038_s41598_023_40463_4 crossref_primary_10_3389_fcimb_2023_1268227 crossref_primary_10_1128_msphere_00883_21 crossref_primary_10_1126_science_abi6226 crossref_primary_10_1021_acsomega_2c03597 crossref_primary_10_1038_s41598_022_19073_z crossref_primary_10_3389_fmicb_2020_01723 crossref_primary_10_1093_oxfmat_itab003 crossref_primary_10_7883_yoken_JJID_2021_018 crossref_primary_10_1016_j_bsheal_2021_06_001 crossref_primary_10_1128_mbio_02558_22 crossref_primary_10_3390_vaccines10081200 crossref_primary_10_3390_pathogens10060721 crossref_primary_10_1002_jmv_26254 crossref_primary_10_1007_s11224_022_01960_w crossref_primary_10_3390_jcm12010142 crossref_primary_10_3390_jox11020006 crossref_primary_10_1073_pnas_2106535118 crossref_primary_10_3390_ijms22094936 crossref_primary_10_3390_ijms23052643 crossref_primary_10_1186_s12915_023_01805_w crossref_primary_10_1111_gtc_12945 crossref_primary_10_1186_s12985_022_01802_5 crossref_primary_10_3389_fcimb_2021_778636 crossref_primary_10_3389_fimmu_2021_641360 crossref_primary_10_1016_j_prp_2022_154000 crossref_primary_10_3390_vaccines11030653 crossref_primary_10_1016_j_mam_2022_101108 crossref_primary_10_1002_jrs_6204 crossref_primary_10_1371_journal_pone_0288634 crossref_primary_10_3389_fphar_2021_757666 crossref_primary_10_3390_nano13172455 crossref_primary_10_1016_j_ebiom_2022_104232 crossref_primary_10_3390_v15122280 crossref_primary_10_1016_j_jhin_2021_09_006 crossref_primary_10_1038_s41598_024_76377_y crossref_primary_10_1016_j_ebiom_2022_104008 crossref_primary_10_7879_siej_23_241 crossref_primary_10_1056_NEJMc2013400 crossref_primary_10_1016_j_antiviral_2023_105766 crossref_primary_10_1128_spectrum_03655_23 crossref_primary_10_3390_ijms23179659 crossref_primary_10_1016_j_scitotenv_2023_164766 crossref_primary_10_1016_j_bioorg_2021_105016 crossref_primary_10_3390_v14010094 crossref_primary_10_1038_s42003_020_1088_9 crossref_primary_10_1016_j_molcel_2020_11_004 crossref_primary_10_1099_acmi_0_000354 crossref_primary_10_1111_1348_0421_12945 crossref_primary_10_3389_fimmu_2023_1258268 crossref_primary_10_1016_j_ejphar_2020_173659 crossref_primary_10_1007_s41664_023_00282_y crossref_primary_10_1111_1751_7915_13592 crossref_primary_10_1039_D3OB01122D crossref_primary_10_1016_j_biopha_2022_113058 crossref_primary_10_1080_14712598_2022_2078160 crossref_primary_10_1038_s41385_020_00340_z crossref_primary_10_1128_jvi_01011_23 crossref_primary_10_1515_revneuro_2020_0136 crossref_primary_10_3390_ijms23020864 crossref_primary_10_3201_eid2702_204088 crossref_primary_10_1186_s12985_021_01542_y crossref_primary_10_2217_nnm_2020_0286 crossref_primary_10_1038_s41596_023_00897_6 crossref_primary_10_1136_jclinpath_2020_206972 crossref_primary_10_3390_ijms232012522 crossref_primary_10_1016_j_virol_2025_110412 crossref_primary_10_3390_ijms25021353 crossref_primary_10_3390_ijms22031308 crossref_primary_10_1016_j_xcrm_2022_100520 crossref_primary_10_1080_07391102_2021_1965658 crossref_primary_10_3389_fcimb_2022_838213 crossref_primary_10_7883_yoken_JJID_2021_292 crossref_primary_10_1007_s00203_021_02727_3 crossref_primary_10_7883_yoken_JJID_2021_055 crossref_primary_10_1038_s41467_020_18764_3 crossref_primary_10_3390_pathogens9060426 crossref_primary_10_1016_j_ijbiomac_2021_06_015 crossref_primary_10_3390_diagnostics10080594 crossref_primary_10_1038_s41467_022_31929_6 crossref_primary_10_1167_iovs_62_7_6 crossref_primary_10_1139_bcb_2021_0342 crossref_primary_10_1016_j_heliyon_2021_e08496 crossref_primary_10_1016_j_jcv_2021_104945 crossref_primary_10_1142_S1793048021300024 crossref_primary_10_1183_13993003_01634_2020 crossref_primary_10_1590_1678_4685_gmb_2020_0452 crossref_primary_10_1016_j_annonc_2020_04_479 crossref_primary_10_21931_RB_2021_05_04_17 crossref_primary_10_3390_v13122434 crossref_primary_10_1038_s41598_023_44484_x crossref_primary_10_1007_s00795_024_00381_4 crossref_primary_10_1016_j_ebiom_2023_104561 crossref_primary_10_1073_pnas_2404175121 crossref_primary_10_1113_JP281499 crossref_primary_10_1371_journal_pone_0248348 crossref_primary_10_1038_s41598_022_21034_5 crossref_primary_10_1007_s11033_021_06333_w crossref_primary_10_1099_jgv_0_002009 crossref_primary_10_1016_j_antiviral_2024_105852 crossref_primary_10_1038_s41467_024_46490_7 crossref_primary_10_1038_s41423_023_01104_y crossref_primary_10_1111_jcmm_16385 crossref_primary_10_3390_jcm9051417 crossref_primary_10_1080_14787210_2020_1812385 crossref_primary_10_3389_fphys_2021_593223 crossref_primary_10_1093_ofid_ofab195 crossref_primary_10_1016_j_vaccine_2022_12_025 crossref_primary_10_3389_fimmu_2022_857490 crossref_primary_10_3917_re1_108_0015 crossref_primary_10_1016_j_heliyon_2020_e04658 crossref_primary_10_1080_25785826_2022_2111905 crossref_primary_10_1128_mBio_00904_21 crossref_primary_10_1016_j_omtn_2021_10_016 crossref_primary_10_1016_j_coviro_2021_02_006 crossref_primary_10_1093_humupd_dmac037 crossref_primary_10_1007_s00210_022_02262_y crossref_primary_10_1038_s41467_024_49415_6 crossref_primary_10_3390_molecules27217413 crossref_primary_10_1016_j_jiac_2021_10_028 crossref_primary_10_1016_j_bbrc_2020_10_094 crossref_primary_10_1186_s12931_024_02718_0 crossref_primary_10_1186_s11658_022_00363_3 crossref_primary_10_7554_eLife_74623 crossref_primary_10_1128_mSphere_00159_21 crossref_primary_10_1080_21645515_2020_1797369 crossref_primary_10_1080_13102818_2022_2047107 crossref_primary_10_1128_JVI_01648_20 crossref_primary_10_1016_j_jece_2023_110592 crossref_primary_10_1038_s41598_022_09218_5 crossref_primary_10_1016_j_cell_2022_04_035 crossref_primary_10_1128_aac_00341_24 crossref_primary_10_1016_j_scitotenv_2020_139076 crossref_primary_10_1111_1348_0421_13165 crossref_primary_10_1128_mBio_02492_20 crossref_primary_10_3389_fneur_2020_01039 crossref_primary_10_3389_fcell_2021_578825 crossref_primary_10_1073_pnas_2025373118 crossref_primary_10_1016_j_jbc_2024_107701 crossref_primary_10_1088_1758_5090_ac32a5 crossref_primary_10_1128_jvi_02217_24 crossref_primary_10_1371_journal_ppat_1010498 crossref_primary_10_1152_physiolgenomics_00089_2020 crossref_primary_10_1021_acs_nanolett_0c02211 crossref_primary_10_1017_ice_2021_8 crossref_primary_10_1016_j_bj_2021_04_006 crossref_primary_10_1016_j_eti_2023_103249 crossref_primary_10_1111_and_14286 crossref_primary_10_25040_ntsh2021_01_05 crossref_primary_10_1016_S2213_2600_20_30238_1 crossref_primary_10_1038_s41598_023_43563_3 crossref_primary_10_3390_jpm12040622 crossref_primary_10_1016_j_bbrc_2020_09_018 crossref_primary_10_1016_j_isci_2022_104295 crossref_primary_10_1016_j_chom_2022_10_003 crossref_primary_10_1186_s12864_025_11393_4 crossref_primary_10_3390_biom11070993 crossref_primary_10_1038_s41467_020_19619_7 crossref_primary_10_1038_s41598_021_84882_7 crossref_primary_10_3389_fphar_2022_952192 crossref_primary_10_1126_sciadv_ade5085 crossref_primary_10_3390_pathogens9110912 crossref_primary_10_1159_000507703 crossref_primary_10_1111_1348_0421_13184 crossref_primary_10_3390_biomedicines10061343 crossref_primary_10_3390_v14061232 crossref_primary_10_3390_v16040520 crossref_primary_10_1016_j_isci_2022_105596 crossref_primary_10_35772_ghm_2022_01060 crossref_primary_10_1038_s41564_022_01105_z crossref_primary_10_1515_jbcpp_2024_0134 crossref_primary_10_1038_s41598_024_75038_4 crossref_primary_10_3390_ijms252111762 crossref_primary_10_1038_s41556_021_00721_x crossref_primary_10_2174_1389201023666220114162347 crossref_primary_10_1128_jcm_00042_24 crossref_primary_10_3389_fgene_2022_801382 crossref_primary_10_3390_microorganisms9102096 crossref_primary_10_3390_v14122682 crossref_primary_10_1038_s41392_022_01249_8 crossref_primary_10_1128_jvi_00286_23 crossref_primary_10_3390_jcm10173885 crossref_primary_10_1038_s41598_021_83295_w crossref_primary_10_1161_CIRCULATIONAHA_120_047549 crossref_primary_10_3389_fmolb_2021_725528 crossref_primary_10_3390_v16040537 crossref_primary_10_3390_ijms22063163 crossref_primary_10_1186_s12934_021_01576_5 crossref_primary_10_26508_lsa_202000786 crossref_primary_10_3390_molecules27196374 crossref_primary_10_1016_j_ejphar_2021_173899 crossref_primary_10_1177_03009858211073678 crossref_primary_10_3390_v12060629 crossref_primary_10_1016_j_ejphar_2020_173372 crossref_primary_10_1038_s41598_021_86037_0 crossref_primary_10_3390_vaccines12101089 crossref_primary_10_2174_1389557521666210805104250 crossref_primary_10_3390_v12060622 crossref_primary_10_1016_j_cytogfr_2020_11_001 crossref_primary_10_1038_s41598_022_17071_9 crossref_primary_10_1073_pnas_2012197117 crossref_primary_10_1055_s_0040_1712155 crossref_primary_10_3390_app14114796 crossref_primary_10_1515_dmpt_2022_0130 crossref_primary_10_3390_v15102052 crossref_primary_10_1016_j_jiac_2021_11_006 crossref_primary_10_3390_biomedicines11123160 crossref_primary_10_1016_j_retram_2022_103348 crossref_primary_10_1126_scitranslmed_abm4908 crossref_primary_10_1007_s00726_021_02991_z crossref_primary_10_1080_08830185_2020_1800688 crossref_primary_10_1016_j_ebiom_2021_103519 crossref_primary_10_1053_j_gastro_2020_04_052 crossref_primary_10_1016_j_jim_2023_113586 crossref_primary_10_1021_acs_jmedchem_0c00606 crossref_primary_10_18632_aging_203532 crossref_primary_10_1016_j_isci_2022_105742 crossref_primary_10_3389_fmicb_2021_660149 crossref_primary_10_2174_1389450121999201125201112 crossref_primary_10_1080_09273948_2022_2054432 crossref_primary_10_1038_s41392_021_00733_x crossref_primary_10_1055_s_0041_1741449 crossref_primary_10_1016_j_talanta_2024_125994 crossref_primary_10_1038_s41598_022_19581_y crossref_primary_10_3390_ijms22179518 crossref_primary_10_1038_s41598_023_29245_0 crossref_primary_10_1038_s41579_024_01036_y crossref_primary_10_3389_fmed_2021_620990 crossref_primary_10_1248_bpb_b22_00503 crossref_primary_10_3390_ijms21082663 crossref_primary_10_3389_fimmu_2023_1270081 crossref_primary_10_5803_jsfm_38_93 crossref_primary_10_3389_fphys_2020_596057 crossref_primary_10_1080_21645515_2020_1842683 crossref_primary_10_3390_molecules26123572 crossref_primary_10_1016_j_cell_2020_12_004 crossref_primary_10_1016_j_metop_2021_100103 crossref_primary_10_1371_journal_pone_0274829 crossref_primary_10_3390_s22103768 crossref_primary_10_1007_s00044_021_02708_7 crossref_primary_10_1007_s00284_023_03315_y crossref_primary_10_1039_D3TA02705H crossref_primary_10_1186_s13293_024_00658_4 crossref_primary_10_1007_s12010_022_03885_w crossref_primary_10_1016_j_jtcme_2021_09_005 crossref_primary_10_1016_j_isci_2022_105720 crossref_primary_10_3389_fphys_2020_00820 crossref_primary_10_5501_wjv_v10_i4_137 crossref_primary_10_1111_1348_0421_13157 crossref_primary_10_2222_jsv_71_33 crossref_primary_10_1016_j_cegh_2020_07_006 crossref_primary_10_1016_j_onehlt_2024_100870 crossref_primary_10_3390_biomedicines11123134 crossref_primary_10_1016_j_jbc_2022_102500 crossref_primary_10_1126_sciadv_abi6110 crossref_primary_10_1371_journal_ppat_1011870 crossref_primary_10_3390_biomedicines10112801 crossref_primary_10_1016_j_dld_2020_09_015 crossref_primary_10_3389_fmicb_2021_651403 crossref_primary_10_1016_j_biochi_2020_05_012 crossref_primary_10_1002_jmv_26911 crossref_primary_10_1002_hsr2_345 crossref_primary_10_1016_j_csbj_2020_12_035 crossref_primary_10_1128_jvi_01663_23 crossref_primary_10_3389_fphar_2025_1537912 crossref_primary_10_1016_j_prp_2021_153647 crossref_primary_10_1016_j_jtho_2021_07_002 crossref_primary_10_1128_jvi_00002_22 crossref_primary_10_1128_spectrum_02381_22 crossref_primary_10_2174_1573402117666210121100201 crossref_primary_10_1016_j_cmi_2021_02_014 crossref_primary_10_1007_s11418_024_01855_6 crossref_primary_10_1038_s41598_021_96109_w crossref_primary_10_1021_acs_analchem_1c04328 crossref_primary_10_3389_fmicb_2020_02016 crossref_primary_10_1016_j_biopha_2023_115940 crossref_primary_10_1007_s12195_020_00642_z crossref_primary_10_1248_bpb_b23_00568 crossref_primary_10_21518_2079_701X_2022_16_4_51_65 crossref_primary_10_1128_msphere_00338_24 crossref_primary_10_1128_spectrum_01789_21 crossref_primary_10_3390_cells9112377 crossref_primary_10_1038_s41586_022_05542_y crossref_primary_10_3389_fmicb_2021_625136 crossref_primary_10_1084_jem_20232192 crossref_primary_10_1016_j_hazadv_2025_100589 crossref_primary_10_1055_s_0040_1715455 crossref_primary_10_1002_cpt_2014 crossref_primary_10_1016_j_ebiom_2021_103544 crossref_primary_10_2142_biophysico_bppb_v18_004 crossref_primary_10_18006_2022_10_5__960_977 crossref_primary_10_3389_fimmu_2021_651728 crossref_primary_10_1002_btm2_10253 crossref_primary_10_3389_fcimb_2021_792584 crossref_primary_10_1172_jci_insight_142386 crossref_primary_10_1016_j_lfs_2020_118313 crossref_primary_10_1016_j_jiac_2020_09_006 crossref_primary_10_1093_jmcb_mjaa047 crossref_primary_10_3390_pathogens11080877 crossref_primary_10_1016_j_bbrc_2023_04_046 crossref_primary_10_1038_s41590_021_00942_0 crossref_primary_10_1248_bpb_b23_00797 crossref_primary_10_1038_s41598_022_12252_y crossref_primary_10_1292_jvms_21_0338 crossref_primary_10_3390_microorganisms10020262 crossref_primary_10_2174_1874467214666210811120635 crossref_primary_10_1016_j_ajic_2020_08_022 crossref_primary_10_1038_s41467_024_47941_x crossref_primary_10_3390_microorganisms11040990 crossref_primary_10_1038_s41598_023_38757_8 crossref_primary_10_1128_msphere_00304_24 crossref_primary_10_1128_spectrum_02859_23 crossref_primary_10_1021_acsinfecdis_0c00365 crossref_primary_10_1016_j_hrtlng_2021_01_016 crossref_primary_10_3390_v14020201 crossref_primary_10_7883_yoken_JJID_2020_1079 crossref_primary_10_1021_acs_jcim_1c00683 crossref_primary_10_1128_JVI_01492_21 crossref_primary_10_1111_bcp_14629 crossref_primary_10_2139_ssrn_4115862 crossref_primary_10_1016_j_jaerosci_2021_105914 crossref_primary_10_1007_s11427_021_1990_5 crossref_primary_10_1016_j_ygeno_2021_08_012 crossref_primary_10_1016_j_ijid_2023_09_010 crossref_primary_10_1186_s13578_022_00822_6 crossref_primary_10_3389_fmicb_2021_701198 crossref_primary_10_1038_s41598_021_97972_3 crossref_primary_10_1038_s41598_024_64103_7 crossref_primary_10_1002_jmv_27132 crossref_primary_10_7883_yoken_JJID_2023_349 crossref_primary_10_1021_acs_analchem_2c04852 crossref_primary_10_15252_embr_202153820 crossref_primary_10_1155_2021_8872412 crossref_primary_10_3390_v14010023 crossref_primary_10_3389_fimmu_2021_565625 crossref_primary_10_1080_20477724_2023_2228048 crossref_primary_10_1016_j_eclinm_2021_100734 crossref_primary_10_37489_0235_2990_2021_66_3_4_62_81 crossref_primary_10_1038_s42003_022_03499_2 crossref_primary_10_1128_jvi_01853_24 crossref_primary_10_2139_ssrn_4171586 crossref_primary_10_1038_s41421_020_00192_8 crossref_primary_10_1016_j_celrep_2021_108959 crossref_primary_10_7759_cureus_54919 crossref_primary_10_1007_s11262_022_01890_z crossref_primary_10_1016_j_biopha_2021_111384 crossref_primary_10_1186_s12985_023_02068_1 crossref_primary_10_3390_v14102239 crossref_primary_10_1007_s00705_021_04961_y crossref_primary_10_3201_eid2609_201353 crossref_primary_10_1038_s42003_022_03586_4 crossref_primary_10_1002_rmv_2321 crossref_primary_10_3390_v13112183 crossref_primary_10_1128_spectrum_01624_24 crossref_primary_10_1016_j_antiviral_2021_105015 crossref_primary_10_1016_j_isci_2021_102322 crossref_primary_10_1042_CS20210735 crossref_primary_10_52586_5043 crossref_primary_10_1016_j_vaccine_2022_08_049 crossref_primary_10_1021_acs_analchem_1c02368 crossref_primary_10_3389_fphar_2021_638334 crossref_primary_10_3389_fcimb_2022_869832 crossref_primary_10_1038_s41467_024_51535_y crossref_primary_10_1371_journal_pone_0287068 crossref_primary_10_3389_fmolb_2022_647826 crossref_primary_10_1016_j_cell_2020_06_011 crossref_primary_10_26442_2075082X_2020_3_200362 crossref_primary_10_1039_D1LC00817J crossref_primary_10_1093_infdis_jiac344 crossref_primary_10_1128_JCM_00527_21 crossref_primary_10_1128_jvi_01992_22 crossref_primary_10_1155_2022_2109641 crossref_primary_10_1038_s42003_021_02856_x crossref_primary_10_3390_pathogens11030302 crossref_primary_10_1128_spectrum_04311_22 crossref_primary_10_1080_01652176_2021_1921311 crossref_primary_10_1186_s40246_021_00330_7 crossref_primary_10_1002_rmv_2342 crossref_primary_10_1016_j_isci_2023_106075 crossref_primary_10_1016_j_ejps_2021_105820 crossref_primary_10_1016_j_cell_2020_06_043 crossref_primary_10_1038_s41467_021_21825_w crossref_primary_10_3390_microorganisms11020534 crossref_primary_10_3390_v15102028 crossref_primary_10_3390_cells11030465 crossref_primary_10_1016_j_ebiom_2024_105181 crossref_primary_10_1038_s41598_022_25418_5 crossref_primary_10_1111_imr_13114 crossref_primary_10_1038_s44298_024_00068_8 crossref_primary_10_1021_acs_jcim_1c01126 crossref_primary_10_1016_j_envres_2020_110317 crossref_primary_10_1080_1061186X_2021_2013852 crossref_primary_10_1128_JVI_00434_21 crossref_primary_10_1038_s41596_020_0394_5 crossref_primary_10_15360_1813_9779_2022_5_18_23 crossref_primary_10_1007_s00347_020_01160_z crossref_primary_10_1099_jgv_0_001821 crossref_primary_10_4155_fmc_2020_0147 crossref_primary_10_1093_jac_dkac257 crossref_primary_10_3390_ijms21155513 crossref_primary_10_1016_j_cell_2022_09_018 crossref_primary_10_1128_mBio_01930_20 crossref_primary_10_1016_j_cct_2021_106509 crossref_primary_10_1016_j_clim_2020_108409 crossref_primary_10_1038_s41586_021_03237_4 crossref_primary_10_3390_v13020161 crossref_primary_10_1038_s41598_021_92940_3 crossref_primary_10_25259_JRHM_10_2021 crossref_primary_10_3390_bioengineering10091068 crossref_primary_10_1038_s12276_024_01197_z crossref_primary_10_1016_j_tips_2020_05_005 crossref_primary_10_3389_fmicb_2020_01576 crossref_primary_10_3390_ijerph18010284 crossref_primary_10_1016_j_bcp_2020_114057 crossref_primary_10_1016_j_ijid_2022_11_003 crossref_primary_10_1016_j_bcp_2020_114296 crossref_primary_10_1016_j_isci_2024_109647 crossref_primary_10_1681_ASN_2020040432 crossref_primary_10_1016_j_isci_2021_102367 crossref_primary_10_1038_s41564_021_00908_w crossref_primary_10_1021_acsomega_1c00363 crossref_primary_10_1093_ofid_ofab430 crossref_primary_10_1111_trf_16056 crossref_primary_10_3390_ijtm2030030 crossref_primary_10_1007_s00439_022_02435_y crossref_primary_10_1038_s41598_021_84733_5 crossref_primary_10_1016_S2213_2600_21_00219_8 crossref_primary_10_1038_s42003_023_05081_w crossref_primary_10_1039_D3CB00166K crossref_primary_10_1038_s41541_022_00493_x crossref_primary_10_3390_v15020271 crossref_primary_10_1016_j_heliyon_2021_e07748 crossref_primary_10_1016_j_celrep_2020_108630 crossref_primary_10_1080_22221751_2021_2012528 crossref_primary_10_1038_s41467_022_35606_6 crossref_primary_10_1007_s00109_024_02423_x crossref_primary_10_1016_j_biopha_2021_111363 crossref_primary_10_1002_jmv_28057 crossref_primary_10_1128_JVI_00807_21 crossref_primary_10_7883_yoken_JJID_2023_353 crossref_primary_10_1038_s41586_021_04266_9 crossref_primary_10_1093_infdis_jiac380 crossref_primary_10_2807_1560_7917_ES_2022_27_18_2200178 crossref_primary_10_1186_s12915_025_02173_3 crossref_primary_10_1186_s13020_020_00393_z crossref_primary_10_1126_sciimmunol_abc3582 crossref_primary_10_3390_v12121420 crossref_primary_10_1186_s12931_023_02397_3 crossref_primary_10_4062_biomolther_2022_037 crossref_primary_10_1038_s41564_022_01135_7 crossref_primary_10_1016_j_stem_2020_09_016 crossref_primary_10_1021_acs_est_1c05296 crossref_primary_10_2139_ssrn_3802855 crossref_primary_10_1038_s42003_022_03630_3 crossref_primary_10_3389_fped_2020_553394 crossref_primary_10_1093_gbe_evad035 crossref_primary_10_1128_mBio_00850_21 crossref_primary_10_1371_journal_pone_0299445 crossref_primary_10_3390_v12050491 crossref_primary_10_7883_yoken_JJID_2020_776 crossref_primary_10_1039_D2RA07356K crossref_primary_10_1073_pnas_2213317120 crossref_primary_10_1002_lary_29324 crossref_primary_10_3390_v15020452 crossref_primary_10_1186_s13578_021_00643_z crossref_primary_10_3390_jimaging8020024 crossref_primary_10_1002_jcla_24146 crossref_primary_10_1002_ange_202411760 crossref_primary_10_3389_fgene_2020_575770 crossref_primary_10_1002_jmv_28990 crossref_primary_10_1111_jam_15284 crossref_primary_10_1080_15459624_2022_2053693 crossref_primary_10_3390_microorganisms11041015 crossref_primary_10_1038_s41598_023_35915_w crossref_primary_10_1038_s41588_020_00759_x crossref_primary_10_1186_s12985_024_02335_9 crossref_primary_10_3389_fimmu_2022_958581 crossref_primary_10_1128_spectrum_01553_21 crossref_primary_10_1681_ASN_2021091209 crossref_primary_10_1016_j_tice_2021_101497 crossref_primary_10_1128_mBio_01935_20 crossref_primary_10_1016_j_antiviral_2022_105372 crossref_primary_10_1016_j_celrep_2023_113212 crossref_primary_10_36303_SAGP_2021_2_5_0092 crossref_primary_10_1038_s41586_020_2577_1 crossref_primary_10_1002_ardp_202100467 crossref_primary_10_1371_journal_ppat_1012171 crossref_primary_10_1007_s00216_023_04825_1 crossref_primary_10_1038_s41467_023_38435_3 crossref_primary_10_3390_microorganisms8101492 crossref_primary_10_3389_fimmu_2024_1363572 crossref_primary_10_1016_j_ijantimicag_2020_106028 crossref_primary_10_1021_acsomega_3c04175 crossref_primary_10_1016_j_jmb_2021_166945 crossref_primary_10_1590_1678_4685_gmb_2020_0198 crossref_primary_10_1016_j_heliyon_2022_e12744 crossref_primary_10_3389_fmicb_2020_01818 crossref_primary_10_3390_v15091855 crossref_primary_10_3390_pathogens12030419 crossref_primary_10_1038_s41598_021_00809_2 crossref_primary_10_1099_jgv_0_001453 crossref_primary_10_1002_2211_5463_13153 crossref_primary_10_1177_2041731420985299 crossref_primary_10_14814_phy2_14707 crossref_primary_10_4062_biomolther_2020_226 crossref_primary_10_1016_j_vph_2021_106829 crossref_primary_10_1016_j_antiviral_2020_104902 crossref_primary_10_1172_JCI142004 crossref_primary_10_1007_s12035_023_03567_6 crossref_primary_10_1038_s41598_023_32269_1 crossref_primary_10_1016_j_cell_2020_10_028 crossref_primary_10_7717_peerj_12681 crossref_primary_10_1016_j_antiviral_2023_105671 crossref_primary_10_3233_CH_209007 crossref_primary_10_1016_j_xpro_2022_101773 crossref_primary_10_1128_jvi_01336_23 crossref_primary_10_5937_jomb0_49377 crossref_primary_10_1093_cid_ciac885 crossref_primary_10_1038_s41586_022_04462_1 crossref_primary_10_1038_s41598_021_86050_3 crossref_primary_10_1093_cid_ciab797 crossref_primary_10_3390_pathogens10020153 crossref_primary_10_1016_j_lfs_2022_120411 crossref_primary_10_1093_cid_ciaa1517 crossref_primary_10_3389_fcvm_2022_862571 crossref_primary_10_1016_j_yjmcc_2021_11_010 crossref_primary_10_1002_jmv_28796 crossref_primary_10_4062_biomolther_2021_048 crossref_primary_10_1136_gutjnl_2020_321269 crossref_primary_10_1055_a_2173_0277 crossref_primary_10_3389_fimmu_2021_803647 crossref_primary_10_1038_s41598_023_47829_8 crossref_primary_10_1111_irv_12860 crossref_primary_10_1128_AAC_00097_21 crossref_primary_10_2144_fsoa_2023_0112 crossref_primary_10_7883_yoken_JJID_2020_108 crossref_primary_10_1007_s11051_022_05485_5 crossref_primary_10_1016_j_csbj_2021_12_011 crossref_primary_10_1038_s43856_024_00488_w crossref_primary_10_1002_path_5549 crossref_primary_10_1002_nano_202100123 crossref_primary_10_1186_s12931_022_02223_2 crossref_primary_10_1016_j_jtos_2020_06_007 crossref_primary_10_1128_mbio_03238_21 crossref_primary_10_1080_22221751_2022_2125345 crossref_primary_10_1128_mbio_01587_23 crossref_primary_10_3390_ijms252312641 crossref_primary_10_1126_scisignal_abg8744 crossref_primary_10_1038_s42003_024_07351_7 crossref_primary_10_1097_INF_0000000000002978 crossref_primary_10_3390_diabetology3010013 crossref_primary_10_3389_fphar_2020_01189 crossref_primary_10_1002_anie_202411760 crossref_primary_10_1111_1348_0421_12828 crossref_primary_10_1038_s41467_023_38457_x crossref_primary_10_1111_cts_12881 crossref_primary_10_1016_j_jksus_2022_102155 crossref_primary_10_1136_bmj_m1313 crossref_primary_10_1016_j_ijid_2023_01_046 crossref_primary_10_1002_jmv_29425 crossref_primary_10_3390_diseases12070157 crossref_primary_10_4167_jbv_2020_50_2_065 crossref_primary_10_3389_fphar_2020_01196 crossref_primary_10_7883_yoken_JJID_2020_324 crossref_primary_10_1002_jmv_27480 crossref_primary_10_3390_genes12020194 crossref_primary_10_1128_jvi_01762_23 crossref_primary_10_1007_s00705_021_05008_y crossref_primary_10_1016_j_pathol_2020_09_012 crossref_primary_10_1073_pnas_2413465122 crossref_primary_10_1093_cid_ciaa1706 crossref_primary_10_1038_s41586_021_03944_y crossref_primary_10_1177_20587384211056840 crossref_primary_10_1016_j_jiac_2021_05_006 crossref_primary_10_1021_acs_molpharmaceut_3c00114 crossref_primary_10_1016_j_vaccine_2022_05_081 crossref_primary_10_1016_j_antiviral_2024_105992 crossref_primary_10_1016_j_bbadis_2022_166527 crossref_primary_10_1016_j_scitotenv_2020_144587 crossref_primary_10_3897_pharmacia_71_e122087 crossref_primary_10_1016_j_eng_2020_10_003 crossref_primary_10_1016_j_ajic_2020_07_022 crossref_primary_10_2174_2666796701999201216101914 crossref_primary_10_1038_s42003_021_02128_8 crossref_primary_10_1128_mSphere_00623_21 crossref_primary_10_31857_S0026898424010176 crossref_primary_10_1159_000512141 crossref_primary_10_1038_s41591_022_01704_7 crossref_primary_10_3390_biomedicines11061658 crossref_primary_10_1002_2211_5463_13337 crossref_primary_10_1016_j_job_2025_100619 crossref_primary_10_1093_cid_ciab986 crossref_primary_10_3389_fmed_2024_1414331 crossref_primary_10_1590_1519_6984_262008 crossref_primary_10_3390_v13030441 crossref_primary_10_3389_fnana_2020_00037 crossref_primary_10_3390_v15051129 crossref_primary_10_14218_ERHM_2020_00055 crossref_primary_10_3390_jcm10194493 crossref_primary_10_1038_s42003_022_04170_6 crossref_primary_10_1111_trf_17622 crossref_primary_10_1016_j_stem_2023_09_001 crossref_primary_10_1016_j_isci_2023_105969 crossref_primary_10_1128_jvi_01366_22 crossref_primary_10_1002_14651858_CD015125 crossref_primary_10_14348_molcells_2021_2249 crossref_primary_10_2139_ssrn_3800855 crossref_primary_10_1371_journal_pone_0312800 crossref_primary_10_1155_tbed_5530007 crossref_primary_10_3389_fnins_2023_1169740 crossref_primary_10_1128_mbio_03523_22 crossref_primary_10_3389_fchem_2025_1395374 crossref_primary_10_1038_s41598_020_78402_2 crossref_primary_10_3390_pathogens11060617 crossref_primary_10_2139_ssrn_3981554 crossref_primary_10_2169_naika_109_2260 crossref_primary_10_1038_s41598_024_71791_8 crossref_primary_10_1073_pnas_2215067120 crossref_primary_10_1093_abt_tbad024 crossref_primary_10_1038_s41587_022_01382_3 crossref_primary_10_1080_22221751_2022_2037397 crossref_primary_10_1038_s41564_022_01170_4 crossref_primary_10_1039_D3LC00768E crossref_primary_10_1128_Spectrum_00783_21 crossref_primary_10_1007_s11033_021_06149_8 crossref_primary_10_1128_mSphere_00647_21 crossref_primary_10_15252_embr_202154305 crossref_primary_10_1016_j_optom_2020_07_002 crossref_primary_10_1016_j_celrep_2021_109218 crossref_primary_10_1134_S1022795421050057 crossref_primary_10_3389_fgene_2020_00942 crossref_primary_10_26508_lsa_202101322 crossref_primary_10_1002_jcp_29868 crossref_primary_10_1099_acmi_0_000465_v3 crossref_primary_10_1146_annurev_med_042320_023055 crossref_primary_10_1016_j_csbj_2021_10_038 crossref_primary_10_3389_fmicb_2023_1137086 crossref_primary_10_1126_science_abd3255 crossref_primary_10_1002_advs_202105187 crossref_primary_10_3390_cancers12082186 crossref_primary_10_1002_smll_202205819 crossref_primary_10_1134_S0026893324020122 crossref_primary_10_1038_s41598_024_80708_4 crossref_primary_10_1002_jmv_28953 crossref_primary_10_1093_abt_tbad001 crossref_primary_10_1016_j_jiac_2021_04_010 crossref_primary_10_1371_journal_pone_0279182 crossref_primary_10_3389_fmicb_2020_02098 crossref_primary_10_1080_14789450_2021_2010549 crossref_primary_10_1128_msphere_00941_21 crossref_primary_10_1021_acs_jnatprod_1c01120 crossref_primary_10_3389_fphar_2021_702472 crossref_primary_10_1371_journal_pone_0312834 crossref_primary_10_1016_j_vaccine_2024_126635 crossref_primary_10_1038_s41467_021_21213_4 crossref_primary_10_4049_jimmunol_2001369 crossref_primary_10_1073_pnas_2404947121 crossref_primary_10_1021_acsomega_0c06335 crossref_primary_10_1007_s11356_020_12165_1 crossref_primary_10_1126_sciadv_abd3916 crossref_primary_10_3390_cells10061419 crossref_primary_10_3390_v16071141 crossref_primary_10_1016_j_cellsig_2022_110334 crossref_primary_10_1016_j_virusres_2024_199478 crossref_primary_10_1038_s41467_023_40182_4 crossref_primary_10_1093_ofid_ofac192 crossref_primary_10_1038_s41586_020_2575_3 crossref_primary_10_1111_irv_13093 crossref_primary_10_1177_10760296211042940 crossref_primary_10_1007_s10096_020_04106_0 crossref_primary_10_3390_jcm9113624 crossref_primary_10_1111_1348_0421_13082 crossref_primary_10_1371_journal_ppat_1010590 crossref_primary_10_3390_jcm10163724 crossref_primary_10_1038_s41586_022_04479_6 crossref_primary_10_3233_TUB_211502 crossref_primary_10_1186_s12917_022_03527_7 crossref_primary_10_1016_j_virusres_2024_199485 crossref_primary_10_1016_j_xpro_2023_102735 |
| Cites_doi | 10.2807/1560-7917.ES.2020.25.3.2000045 10.1073/pnas.0505577102 10.1099/vir.0.81749-0 10.1128/JVI.00683-18 10.1007/s00705-006-0924-7 10.1128/JVI.01890-13 10.1128/JVI.01815-18 10.1038/s41586-020-2008-3 10.1038/s41586-020-2012-7 10.1056/NEJMoa2001017 10.1128/JVI.01542-10 10.1016/S0140-6736(20)30251-8 10.1128/JVI.00128-13 10.1128/JVI.02062-10 10.7883/yoken.JJID.2020.061 |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 the Author(s). Published by PNAS. Copyright National Academy of Sciences Mar 31, 2020 Copyright © 2020 the Author(s). Published by PNAS. 2020 |
| Copyright_xml | – notice: Copyright © 2020 the Author(s). Published by PNAS. – notice: Copyright National Academy of Sciences Mar 31, 2020 – notice: Copyright © 2020 the Author(s). Published by PNAS. 2020 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM |
| DOI | 10.1073/pnas.2002589117 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts Ecology Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Entomology Abstracts Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Virology and AIDS Abstracts CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 1091-6490 |
| EndPage | 7003 |
| ExternalDocumentID | PMC7132130 32165541 10_1073_pnas_2002589117 26929415 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Japan Agency for Medical Research and Development (AMED) grantid: 19fk0108111j0001 – fundername: Japan Agency for Medical Research and Development (AMED) grantid: JP19fk0108030j0403 – fundername: MEXT | Japan Society for the Promotion of Science (JSPS) grantid: 18H02665 – fundername: Japan Agency for Medical Research and Development (AMED) grantid: JP19fk0108104 – fundername: Japan Agency for Medical Research and Development (AMED) grantid: JP19fk0108058j0802 – fundername: MEXT | Japan Society for the Promotion of Science (JSPS) grantid: 17K08868 |
| GroupedDBID | --- -DZ -~X .55 0R~ 123 29P 2AX 2FS 2WC 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACHIC ACIWK ACNCT ACPRK ADQXQ AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM BKOMP CS3 D0L DCCCD DIK DU5 E3Z EBS F5P FRP GX1 H13 HH5 HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST KQ8 L7B LU7 N9A N~3 O9- OK1 PNE PQQKQ R.V RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR W8F WH7 WOQ WOW X7M XSW Y6R YBH YKV YSK ZCA ~02 ~KM AAYXX CITATION CGR CUY CVF DOOOF ECM EIF NPM RHF VQA YIF YIN 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c509t-32c3389f86b6c8ca9d66ec75ba2088700835d6e30a371a25c7f856a261dc944c3 |
| ISSN | 0027-8424 1091-6490 |
| IngestDate | Thu Aug 21 18:00:46 EDT 2025 Fri Jul 11 05:24:49 EDT 2025 Mon Jun 30 08:33:01 EDT 2025 Wed Feb 19 02:29:48 EST 2025 Tue Jul 01 03:40:18 EDT 2025 Thu Apr 24 23:03:53 EDT 2025 Thu May 29 09:12:48 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 13 |
| Keywords | VeroE6 TMPRSS2 coronavirus outbreak SARS-CoV-2 |
| Language | English |
| License | Copyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY). |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c509t-32c3389f86b6c8ca9d66ec75ba2088700835d6e30a371a25c7f856a261dc944c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: S.M., N. Nao, K.S., and M. Takeda designed research; S.M., N. Nao, K.S., M. Kawase, S.S., I.T., N. Nagata, T. Sekizuka, H.K., F.K., M.S., M. Tahara, M. Kuroda, T. Suzuki, and T.K. performed research; S.K. and N.O. contributed new reagents/analytic tools; S.M., N. Nao, K.S., T. Sekizuka, M. Kuroda, T.K., and M. Takeda analyzed data; and S.M. and M. Takeda wrote the paper. Edited by Yuan Chang, University of Pittsburgh, Pittsburgh, PA, and approved March 5, 2020 (received for review February 11, 2020) |
| ORCID | 0000-0002-8613-4717 0000-0002-1302-5472 0000-0002-3820-9542 0000-0002-8194-7727 0000-0002-0487-4405 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7132130 |
| PMID | 32165541 |
| PQID | 2387487573 |
| PQPubID | 42026 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7132130 proquest_miscellaneous_2377343324 proquest_journals_2387487573 pubmed_primary_32165541 crossref_primary_10_1073_pnas_2002589117 crossref_citationtrail_10_1073_pnas_2002589117 jstor_primary_26929415 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-03-31 |
| PublicationDateYYYYMMDD | 2020-03-31 |
| PublicationDate_xml | – month: 03 year: 2020 text: 2020-03-31 day: 31 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Washington |
| PublicationSeriesTitle | Brief Report |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 2020 |
| Publisher | National Academy of Sciences |
| Publisher_xml | – name: National Academy of Sciences |
| References | e_1_3_4_2_2 e_1_3_4_1_2 Matsuyama S. (e_1_3_4_14_2) 2018; 92 Corman V. M. (e_1_3_4_9_2) 2020; 25 Mizutani T. (e_1_3_4_8_2) 2007; 152 Shirato K. (e_1_3_4_12_2) 2013; 87 Gierer S. (e_1_3_4_15_2) 2013; 87 Zhu N. (e_1_3_4_4_2) 2020; 382 e_1_3_4_10_2 Iwata-Yoshikawa N. (e_1_3_4_6_2) 2019; 93 Simmons G. (e_1_3_4_13_2) 2005; 102 Matsuyama S. (e_1_3_4_5_2) 2010; 84 Ren X. (e_1_3_4_7_2) 2006; 87 Lu R. (e_1_3_4_3_2) 2020; 395 Shulla A. (e_1_3_4_11_2) 2011; 85 32360584 - Pharmacol Res. 2020 Jul;157:104853 |
| References_xml | – volume: 25 start-page: 2000045 year: 2020 ident: e_1_3_4_9_2 article-title: Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR publication-title: Euro. Surveill. doi: 10.2807/1560-7917.ES.2020.25.3.2000045 – volume: 102 start-page: 11876 year: 2005 ident: e_1_3_4_13_2 article-title: Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0505577102 – volume: 87 start-page: 1691 year: 2006 ident: e_1_3_4_7_2 article-title: Analysis of ACE2 in polarized epithelial cells: Surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus publication-title: J. Gen. Virol. doi: 10.1099/vir.0.81749-0 – volume: 92 start-page: e00683-18 year: 2018 ident: e_1_3_4_14_2 article-title: Middle East respiratory syndrome coronavirus spike protein is not activated directly by cellular furin during viral entry into target cells publication-title: J. Virol. doi: 10.1128/JVI.00683-18 – volume: 152 start-page: 1019 year: 2007 ident: e_1_3_4_8_2 article-title: Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans publication-title: Arch. Virol. doi: 10.1007/s00705-006-0924-7 – volume: 87 start-page: 12552 year: 2013 ident: e_1_3_4_12_2 article-title: Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2 publication-title: J. Virol. doi: 10.1128/JVI.01890-13 – volume: 93 start-page: e01815-18 year: 2019 ident: e_1_3_4_6_2 article-title: TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection publication-title: J. Virol. doi: 10.1128/JVI.01815-18 – ident: e_1_3_4_1_2 doi: 10.1038/s41586-020-2008-3 – ident: e_1_3_4_2_2 doi: 10.1038/s41586-020-2012-7 – volume: 382 start-page: 727 year: 2020 ident: e_1_3_4_4_2 article-title: A novel coronavirus from patients with pneumonia in China, 2019 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2001017 – volume: 84 start-page: 12658 year: 2010 ident: e_1_3_4_5_2 article-title: Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2 publication-title: J. Virol. doi: 10.1128/JVI.01542-10 – volume: 395 start-page: 565 year: 2020 ident: e_1_3_4_3_2 article-title: Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding publication-title: Lancet doi: 10.1016/S0140-6736(20)30251-8 – volume: 87 start-page: 5502 year: 2013 ident: e_1_3_4_15_2 article-title: The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies publication-title: J. Virol. doi: 10.1128/JVI.00128-13 – volume: 85 start-page: 873 year: 2011 ident: e_1_3_4_11_2 article-title: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry publication-title: J. Virol. doi: 10.1128/JVI.02062-10 – ident: e_1_3_4_10_2 doi: 10.7883/yoken.JJID.2020.061 – reference: 32360584 - Pharmacol Res. 2020 Jul;157:104853 |
| SSID | ssj0009580 |
| Score | 2.723751 |
| Snippet | A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December... |
| SourceID | pubmedcentral proquest pubmed crossref jstor |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 7001 |
| SubjectTerms | Animals Betacoronavirus - isolation & purification Biological Sciences BRIEF REPORTS Cell Line Chlorocebus aethiops Coronavirus Infections - virology Coronaviruses COVID-19 Disease Outbreaks Humans Pandemics Pneumonia, Viral - virology Respiratory diseases RNA, Viral - metabolism SARS-CoV-2 Serine Endopeptidases - metabolism Severe acute respiratory syndrome coronavirus 2 Vero Cells Viral diseases Virus Cultivation |
| Title | Enhanced isolation of SARS-CoV-2 by TMPRSS2- expressing cells |
| URI | https://www.jstor.org/stable/26929415 https://www.ncbi.nlm.nih.gov/pubmed/32165541 https://www.proquest.com/docview/2387487573 https://www.proquest.com/docview/2377343324 https://pubmed.ncbi.nlm.nih.gov/PMC7132130 |
| Volume | 117 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Rb9MwELZgvPCCGDAIDBQkHoamlMZO7FTipZo6TWgt1dqivkWO46zRSoLWRND9es5x4qalSIOXqHJsp_Kdz9_Zvu8Q-kBkL8aUdR2fu4pU2w2cwIf5GAEa9xiLaIRV7PBwRC9m3pe5P9-JLimijrjbG1fyP1KFMpCripL9B8maTqEAfoN84QkShue9ZDzIFvoAP4XvGOw36V9NnLP8m4MVtpwOx1eTCXbkL33lVcXYyuVy1UalY7OKrZo7A6Nmk7C_CTmp7cDq1Dkdj_qtzexiVa759wqGThZlkd-UZo-Z59qGX_Msv03Nfs6iOt7X1znuoLGx-_wn16keh-m6vEnbmxLggdZResaOAgxxqKczgXbknrLG-OrIzUbLSMuWqhPxvUYerJLKTJzxim4dq7yIdS9bdNqjr-H57PIynA7m04foEQY_AleWu83KHGi6ivqfNdxPjHza6X4Ltuibq_t8kt2rtS2sMn2KntROht3XGnOIHsjsGTpsxGef1FzjH5-jz40K2UaF7DyxNypkR2v7TxWyKxV6gWbng-nZhVMn1HAE4MLCIVgQAKhJQCMqAsF7MaVSMD_iWC02FRyPqSRdTpjLsS9YAhOXg5Mdi57nCXKEDrI8k6-Q3Y0TFos46sUwH2WCIyEADPpJBIgX1gVpoU4zXqGo2eZV0pNlWN16YCRUAxxuBthCJ6bBD0208veqR5UATD1MAeQDErXQcSORsJ6m0I4ETHnljFjovXkNRlSNFM9kXqo6jBHF5OdZ6KUWoOmcYJcC5nYtxLZEayoogvbtN1m6qIjamQuNSff1Pb77Bj3ezKNjdFDclvItwN0ielep7G_Km6ag |
| linkProvider | ABC ChemistRy |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Enhanced+isolation+of+SARS-CoV-2+by+TMPRSS2-expressing+cells&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Matsuyama%2C+Shutoku&rft.au=Nao%2C+Naganori&rft.au=Shirato%2C+Kazuya&rft.au=Kawase%2C+Miyuki&rft.date=2020-03-31&rft.issn=1091-6490&rft.eissn=1091-6490&rft.volume=117&rft.issue=13&rft.spage=7001&rft_id=info:doi/10.1073%2Fpnas.2002589117&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0027-8424&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0027-8424&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0027-8424&client=summon |