Structures and implications of TBP–nucleosome complexes

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 30; pp. 1 - 7
• Main Authors: Xionga, Le, Cramer, Patrick
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.07.2021
• Series: Inaugural Article
• Subjects: Assembly; Bends; Biological Sciences; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - metabolism; Electron microscopy; Eukaryotes; Histones; INAUGURAL ARTICLE; Models, Molecular; Nucleosomes - chemistry; Nucleosomes - metabolism; Protein Binding; Protein Conformation; Saccharomyces cerevisiae - metabolism; Superhelical DNA; Tata box; TATA-binding protein; TATA-Box Binding Protein - metabolism; Transcription Factor TFIIA - genetics; Transcription Factor TFIIA - metabolism; Transcription Factor TFIIB - genetics; Transcription Factor TFIIB - metabolism; Transcription factors; Transcription initiation factor TFIIA; Transcription initiation factor TFIIB; Yeast; nucleosome; gene transcription; structural biology; chromatin; RNA polymerase II

The TATA box-binding protein (TBP) is highly conserved throughout eukaryotes and plays a central role in the assembly of the transcription preinitiation complex (PIC) at gene promoters. TBP binds and bends DNA, and directs adjacent binding of the transcription factors TFIIA and TFIIB for PIC assembl...