The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells

• Published in: The Journal of biological chemistry Vol. 288; no. 25; pp. 18439 - 18447
• Main Authors: Sharma, Amit, Diecke, Sebastian, Zhang, Wendy Y., Lan, Feng, He, Chunjiang, Mordwinkin, Nicholas M., Chua, Katrin F., Wu, Joseph C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.06.2013; American Society for Biochemistry and Molecular Biology
• Subjects: Adolescent; Age Factors; Aging; Aging - genetics; Aging - physiology; Cell Biology; Cells, Cultured; Cellular Reprogramming - genetics; Cellular Reprogramming - physiology; Cluster Analysis; Dermis - cytology; Embryoid Bodies - metabolism; Embryoid Bodies - physiology; Embryonic Stem Cell; Fibroblasts - cytology; Fibroblasts - metabolism; Fibroblasts - physiology; Gene Expression; Gene Expression Profiling; Humans; Immunohistochemistry; Induced pluripotent Stem Cells; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - physiology; MicroRNA; MicroRNAs - genetics; Middle Aged; Models, Genetic; Molecular Biology; Pluripotent Stem Cells - metabolism; Pluripotent Stem Cells - physiology; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; Sirtuins - genetics; Sirtuins - metabolism; Sirtuins - physiology; Transcription Factors; Gene Expression; MicroRNA; Induced pluripotent Stem Cells; Molecular Biology; Aging; Transcription Factors; Embryonic Stem Cell

Aging is known to be the single most important risk factor for multiple diseases. Sirtuin 6, or SIRT6, has recently been identified as a critical regulator of transcription, genome stability, telomere integrity, DNA repair, and metabolic homeostasis. A knockout mouse model of SIRT6 has displayed dra...