Malignant mesothelioma in situ: morphologic features and clinical outcome

• Published in: Modern pathology Vol. 33; no. 2; pp. 297 - 302
• Main Authors: Churg, Andrew, Galateau-Salle, Francoise, Roden, Anja C., Attanoos, Richard, von der Thusen, Jan H., Tsao, Ming-Sound, Chang, Nina, De Perrot, Marc, Dacic, Sanja
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2020; Elsevier Limited
• Subjects: 13/51; 5'-Methylthioadenosine phosphorylase; 631/67; 692/53; Aged; Asbestos; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Biopsy; Cell Proliferation; Clinical outcomes; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Disease Progression; Effusion; Etiology; Female; Humans; Immunohistochemistry; Invasiveness; Laboratory Medicine; Lung cancer; Male; Medicine; Medicine & Public Health; Mesothelioma; Mesothelioma, Malignant - enzymology; Mesothelioma, Malignant - genetics; Mesothelioma, Malignant - pathology; Mesothelioma, Malignant - therapy; Mesothelium; Middle Aged; Neoplasm Invasiveness; Pathology; Peritoneal Neoplasms - enzymology; Peritoneal Neoplasms - genetics; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - therapy; Peritoneum; Phosphorylase; Plaques; Pleura; Pleural Neoplasms - enzymology; Pleural Neoplasms - genetics; Pleural Neoplasms - pathology; Pleural Neoplasms - therapy; Purine-Nucleoside Phosphorylase - analysis; Time Factors; Treatment Outcome; Tumor Suppressor Proteins - genetics; Ubiquitin Thiolesterase - genetics

The existence of an in situ phase of malignant mesothelioma has long been postulated but until recently has been impossible to prove. Here we describe ten patients with mesothelioma in situ, defined by a single layer of surface mesothelial cells showing loss of BAP1 nuclear immunostaining, no eviden...