Talin folding as the tuning fork of cellular mechanotransduction

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 35; pp. 21346 - 21353
• Main Authors: Tapia-Rojo, Rafael, Alonso-Caballero, Álvaro, Fernández, Julio M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 01.09.2020
• Subjects: Bandpass filters; Biological Sciences; Folding; Frequency dependence; Frequency ranges; Magnetic tape; Mechanical stimuli; Mechanotransduction; Mechanotransduction, Cellular; Noise; Physical Sciences; Protein Domains; Protein Folding; Proteins; Single Molecule Imaging; Stochastic resonance; Talin; Talin - physiology; stochastic resonance; protein folding; magnetic tweezers; talin

Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics...