New insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm

Abstract In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer’s disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in Alzheimer’s disease. Seladin-1 was considered a novel neuroprotective factor, because of its anti-apoptotic properties. Subsequentl...

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Published in	Frontiers in neuroendocrinology Vol. 30; no. 2; pp. 119 - 129
Main Authors	Peri, Alessandro, Danza, Giovanna, Benvenuti, Susanna, Luciani, Paola, Deledda, Cristiana, Rosati, Fabiana, Cellai, Ilaria, Serio, Mario
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.07.2009
Subjects	Alzheimer’s disease Animals Brain Cholesterol Cholesterol - chemistry Cholesterol - metabolism DHCR24 Endocrinology & Metabolism Estrogens Estrogens - chemistry Estrogens - metabolism Humans Molecular Structure Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroblast Neurodegeneration Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Neuroprotective Agents - metabolism Oxidoreductases Acting on CH-CH Group Donors - genetics Oxidoreductases Acting on CH-CH Group Donors - metabolism Plant Proteins - genetics Plant Proteins - metabolism Seladin-1 Brain Alzheimer’s disease Neurodegeneration Seladin-1 Estrogens DHCR24 Neuroblast Cholesterol
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Abstract	Abstract In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer’s disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in Alzheimer’s disease. Seladin-1 was considered a novel neuroprotective factor, because of its anti-apoptotic properties. Subsequently, it has been demonstrated that seladin-1 corresponds to the gene that encodes 3-beta-hydroxysterol delta-24-reductase ( DHCR24 ), that catalyzes the synthesis of cholesterol from desmosterol. There is evidence that cholesterol plays a fundamental role in maintaining brain homeostasis. Because of its enzymatic activity, seladin-1/DHCR24 has been considered the human homolog of the plant protein DIMINUTO/DWARF1, that is involved in the synthesis of sterol plant hormones. We have recently demonstrated that seladin-1/DHCR24 is a fundamental mediator of the protective effects of estrogens in the brain. This review describes how this protein interacts with cholesterol and estrogens, thus generating a neuroprotective network, that might open new possibilities in the prevention/treatment of neurodegenerative diseases.
AbstractList	In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer's disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in Alzheimer's disease. Seladin-1 was considered a novel neuroprotective factor, because of its anti-apoptotic properties. Subsequently, it has been demonstrated that seladin-1 corresponds to the gene that encodes 3-beta-hydroxysterol delta-24-reductase (DHCR24), that catalyzes the synthesis of cholesterol from desmosterol. There is evidence that cholesterol plays a fundamental role in maintaining brain homeostasis. Because of its enzymatic activity, seladin-1/DHCR24 has been considered the human homolog of the plant protein DIMINUTO/DWARF1, that is involved in the synthesis of sterol plant hormones. We have recently demonstrated that seladin-1/DHCR24 is a fundamental mediator of the protective effects of estrogens in the brain. This review describes how this protein interacts with cholesterol and estrogens, thus generating a neuroprotective network, that might open new possibilities in the prevention/treatment of neurodegenerative diseases. Abstract In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer’s disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in Alzheimer’s disease. Seladin-1 was considered a novel neuroprotective factor, because of its anti-apoptotic properties. Subsequently, it has been demonstrated that seladin-1 corresponds to the gene that encodes 3-beta-hydroxysterol delta-24-reductase ( DHCR24 ), that catalyzes the synthesis of cholesterol from desmosterol. There is evidence that cholesterol plays a fundamental role in maintaining brain homeostasis. Because of its enzymatic activity, seladin-1/DHCR24 has been considered the human homolog of the plant protein DIMINUTO/DWARF1, that is involved in the synthesis of sterol plant hormones. We have recently demonstrated that seladin-1/DHCR24 is a fundamental mediator of the protective effects of estrogens in the brain. This review describes how this protein interacts with cholesterol and estrogens, thus generating a neuroprotective network, that might open new possibilities in the prevention/treatment of neurodegenerative diseases. In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer’s disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in Alzheimer’s disease. Seladin-1 was considered a novel neuroprotective factor, because of its anti-apoptotic properties. Subsequently, it has been demonstrated that seladin-1 corresponds to the gene that encodes 3-beta-hydroxysterol delta-24-reductase ( DHCR24), that catalyzes the synthesis of cholesterol from desmosterol. There is evidence that cholesterol plays a fundamental role in maintaining brain homeostasis. Because of its enzymatic activity, seladin-1/DHCR24 has been considered the human homolog of the plant protein DIMINUTO/DWARF1, that is involved in the synthesis of sterol plant hormones. We have recently demonstrated that seladin-1/DHCR24 is a fundamental mediator of the protective effects of estrogens in the brain. This review describes how this protein interacts with cholesterol and estrogens, thus generating a neuroprotective network, that might open new possibilities in the prevention/treatment of neurodegenerative diseases.
Author	Deledda, Cristiana Danza, Giovanna Benvenuti, Susanna Luciani, Paola Cellai, Ilaria Rosati, Fabiana Serio, Mario Peri, Alessandro
Author_xml	– sequence: 1 fullname: Peri, Alessandro – sequence: 2 fullname: Danza, Giovanna – sequence: 3 fullname: Benvenuti, Susanna – sequence: 4 fullname: Luciani, Paola – sequence: 5 fullname: Deledda, Cristiana – sequence: 6 fullname: Rosati, Fabiana – sequence: 7 fullname: Cellai, Ilaria – sequence: 8 fullname: Serio, Mario
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19351544$$D View this record in MEDLINE/PubMed
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Snippet	Abstract In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer’s disease indicator-1) was identified and found to be down regulated in vulnerable brain... In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer’s disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in... In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer's disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in...
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SubjectTerms	Alzheimer’s disease Animals Brain Cholesterol Cholesterol - chemistry Cholesterol - metabolism DHCR24 Endocrinology & Metabolism Estrogens Estrogens - chemistry Estrogens - metabolism Humans Molecular Structure Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroblast Neurodegeneration Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Neuroprotective Agents - metabolism Oxidoreductases Acting on CH-CH Group Donors - genetics Oxidoreductases Acting on CH-CH Group Donors - metabolism Plant Proteins - genetics Plant Proteins - metabolism Seladin-1
Title	New insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm
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