Targeting the Immune Microenvironment in Lymphomas of B-Cell Origin: From Biology to Clinical Application

In lymphomas of B-cell origin, cancer cells orchestrate an inflammatory microenvironment of immune and stromal cells that sustain the tumor cell survival and growth, known as a tumor microenvironment (TME). The features of the TME differ between the different lymphoma types, ranging from extremely i...

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Published inCancers Vol. 11; no. 7; p. 915
Main Authors Mulder, Tom A, Wahlin, Björn E, Österborg, Anders, Palma, Marzia
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.06.2019
MDPI
Subjects
Anergy
Bone marrow
Cancer
Cell survival
Chronic lymphocytic leukemia
Clinical trials
Drug delivery
Drug development
Gene expression
Genotype & phenotype
Hodgkin's lymphoma
Immunosuppressive agents
Inflammation
Lymphatic leukemia
Lymphocytes
Lymphocytes B
Lymphoma
Medical prognosis
Medicin och hälsovetenskap
Review
Reviews
Stromal cells
Tumor microenvironment
Tumors
macrophages
PD-L1
immune cells
CD47
tumor microenvironment
T cells
PD-1
B-cell lymphoma
Hodgkin lymphoma
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Abstract In lymphomas of B-cell origin, cancer cells orchestrate an inflammatory microenvironment of immune and stromal cells that sustain the tumor cell survival and growth, known as a tumor microenvironment (TME). The features of the TME differ between the different lymphoma types, ranging from extremely inflammatory, such as in Hodgkin lymphoma, to anergic, leading to immune deficiency and susceptibility to infections, such as in chronic lymphocytic leukemia. Understanding the characteristic features of the TME as well as the interactions between cancer and TME cells has given insight into the pathogenesis of most lymphomas and contributed to identify novel therapeutic targets. Here, we summarize the preclinical data that contributed to clarifying the role of the immune cells in the TME of different types of lymphomas of B-cell origin, and explain how the understanding of the biological background has led to new clinical applications. Moreover, we provide an overview of the clinical results of trials that assessed the safety and efficacy of drugs directly targeting TME immune cells in lymphoma patients.
AbstractList In lymphomas of B-cell origin, cancer cells orchestrate an inflammatory microenvironment of immune and stromal cells that sustain the tumor cell survival and growth, known as a tumor microenvironment (TME). The features of the TME differ between the different lymphoma types, ranging from extremely inflammatory, such as in Hodgkin lymphoma, to anergic, leading to immune deficiency and susceptibility to infections, such as in chronic lymphocytic leukemia. Understanding the characteristic features of the TME as well as the interactions between cancer and TME cells has given insight into the pathogenesis of most lymphomas and contributed to identify novel therapeutic targets. Here, we summarize the preclinical data that contributed to clarifying the role of the immune cells in the TME of different types of lymphomas of B-cell origin, and explain how the understanding of the biological background has led to new clinical applications. Moreover, we provide an overview of the clinical results of trials that assessed the safety and efficacy of drugs directly targeting TME immune cells in lymphoma patients.
Author Wahlin, Björn E
Mulder, Tom A
Palma, Marzia
Österborg, Anders
AuthorAffiliation 2 Department of Hematology, Karolinska University Hospital, 171 76 Stockholm, Sweden
1 Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden
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  givenname: Tom A
  surname: Mulder
  fullname: Mulder, Tom A
  organization: Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
– sequence: 2
  givenname: Björn E
  surname: Wahlin
  fullname: Wahlin, Björn E
  organization: Department of Hematology, Karolinska University Hospital, Stockholm, Sweden
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  givenname: Anders
  surname: Österborg
  fullname: Österborg, Anders
  organization: Department of Hematology, Karolinska University Hospital, Stockholm, Sweden
– sequence: 4
  givenname: Marzia
  surname: Palma
  fullname: Palma, Marzia
  email: marzia.palma@sll.se, marzia.palma@sll.se
  organization: Department of Hematology, Karolinska University Hospital, Stockholm, Sweden. marzia.palma@sll.se
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2019 by the authors. 2019
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Keywords macrophages
PD-L1
immune cells
CD47
tumor microenvironment
T cells
PD-1
B-cell lymphoma
Hodgkin lymphoma
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SSID ssj0000331767
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SecondaryResourceType review_article
Snippet In lymphomas of B-cell origin, cancer cells orchestrate an inflammatory microenvironment of immune and stromal cells that sustain the tumor cell survival and...
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SubjectTerms Anergy
Bone marrow
Cancer
Cell survival
Chronic lymphocytic leukemia
Clinical trials
Drug delivery
Drug development
Gene expression
Genotype & phenotype
Hodgkin's lymphoma
Immunosuppressive agents
Inflammation
Lymphatic leukemia
Lymphocytes
Lymphocytes B
Lymphoma
Medical prognosis
Medicin och hälsovetenskap
Review
Reviews
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Title Targeting the Immune Microenvironment in Lymphomas of B-Cell Origin: From Biology to Clinical Application
URI https://www.ncbi.nlm.nih.gov/pubmed/31261914
https://www.proquest.com/docview/2547484663
https://search.proquest.com/docview/2251102016
https://pubmed.ncbi.nlm.nih.gov/PMC6678966
http://kipublications.ki.se/Default.aspx?queryparsed=id:141943725
Volume 11
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