Aryl Hydrocarbon Receptor Activation by Dioxin Targets Phosphoenolpyruvate Carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-inducible Poly(ADP-ribose) Polymerase (TiPARP)

• Published in: The Journal of biological chemistry Vol. 288; no. 30; pp. 21514 - 21525
• Main Authors: Diani-Moore, Silvia, Zhang, Sheng, Ram, Payal, Rifkind, Arleen B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.07.2013; American Society for Biochemistry and Molecular Biology
• Subjects: Adenosine Diphosphate Ribose - metabolism; ADP-ribosylation; Amino Acid Sequence; Animals; Aryl Hydrocarbon Receptor; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Chick Embryo; Chickens; Dioxin; Enzymology; Gene Expression; HEK293 Cells; Hep G2 Cells; Hepatocytes - cytology; Hepatocytes - drug effects; Hepatocytes - metabolism; Humans; Liver; Molecular Sequence Data; Phosphoenolpyruvate Carboxykinase; Phosphoenolpyruvate Carboxykinase (ATP) - genetics; Phosphoenolpyruvate Carboxykinase (ATP) - metabolism; Poly(ADP-ribose) Polymerases - genetics; Poly(ADP-ribose) Polymerases - metabolism; Polychlorinated Dibenzodioxins - pharmacology; Protein Processing, Post-Translational - drug effects; Proteomics; Rats; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Tandem Mass Spectrometry; TiPARP; TiPARP; Aryl Hydrocarbon Receptor; Phosphoenolpyruvate Carboxykinase; Dioxin; Liver; ADP-ribosylation

Effects of the environmental toxin and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) include a wasting syndrome associated with decreased gluconeogenesis. TCDD is a potent activator of the aryl hydrocarbon receptor (AHR), a ligand activated transcription factor. The relationship betw...