SUMOylation of the Farnesoid X Receptor (FXR) Regulates the Expression of FXR Target Genes

• Published in: The Journal of biological chemistry Vol. 288; no. 19; pp. 13850 - 13862
• Main Authors: Balasubramaniyan, Natarajan, Luo, Yuhuan, Sun, An-Qiang, Suchy, Frederick J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.05.2013; American Society for Biochemistry and Molecular Biology
• Subjects: ABC Transporter; Amino Acid Motifs; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters - genetics; Bile Acid Transporters; Cholestasis; Cholestasis - metabolism; Chromatin - metabolism; Chromatin Histone Modification; Consensus Sequence; Gene Expression Regulation; Gene Knockdown Techniques; Gene Regulation; Gene Transcription; Hep G2 Cells; Histone Modifications; Humans; Liver - metabolism; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Nuclear Receptors; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Receptors, Cytoplasmic and Nuclear - chemistry; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; RNA, Small Interfering - genetics; Small Ubiquitin-Related Modifier Proteins - genetics; Small Ubiquitin-Related Modifier Proteins - metabolism; SUMO-1 Protein - genetics; SUMO-1 Protein - metabolism; Sumoylation; Transcription, Genetic; Chromatin Histone Modification; Gene Regulation; Gene Transcription; Bile Acid Transporters; ABC Transporter; Histone Modifications; Nuclear Receptors; Cholestasis

The farnesoid X receptor (FXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metabolism including bile acid homeostasis. Here we show that FXR is covalently modified by the small ubiquitin-like modifier (Sumo1), an important regulator of cell signaling a...