Proteomic Analysis of Plasma-Derived Extracellular Vesicles From Mice With Echinococcus granulosus at Different Infection Stages and Their Immunomodulatory Functions
The globally distributed cystic echinococcosis (CE) is caused by the larval stage of ( ), a cosmopolitan and zoonotic disease with potentially life-threatening complications in humans. The emerging roles for extracellular vesicles (EVs) in parasitic infection include transferring proteins and modify...
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| Published in | Frontiers in cellular and infection microbiology Vol. 12; p. 805010 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Media S.A
10.03.2022
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| Abstract | The globally distributed cystic echinococcosis (CE) is caused by the larval stage of
(
), a cosmopolitan and zoonotic disease with potentially life-threatening complications in humans. The emerging roles for extracellular vesicles (EVs) in parasitic infection include transferring proteins and modifying host cell gene expression to modulate host immune responses. Few studies focused on the host-derived EVs and its protein profiles. We focused on the EVs from mouse infected with
at different stages. ExoQuick kit was used for isolating EVs from mouse plasma and ExoEasy Maxi kit was used for isolating protoscolex culture supernatant (PCS) and hydatid cyst fluid (HCF). Firstly, EVs were characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and immunoblot. Secondly, the proteins of plasma EVs were identified using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The resulting LC-MS/MS data were processed using Maxquant search engine (v 1.5.2.8). Tandem mass spectra were researched against the mice and
proteins database in the NCBI. The differentially expressed proteins are performed by proteomic label-free quantitative analysis and bioinformatics. Thirdly,
experiment, the results of co-culture of plasma EVs and spleen mononuclear cells showed that 7W-EVs can increase the relative abundance of regulatory T (Treg) cells and IL-10. We further verified that EVs can be internalized by CD4
and CD8
T cells, B cells, and myeloid-derived suppressor cells (MDSC). These results implied host-derived EVs are multidirectional immune modulators. The findings can contribute to a better understanding of the role of host-derived EVs which are the optimal vehicle to transfer important cargo into host immune system. In addition, we have found several important proteins associated with
and identified in infected mouse plasma at different stages. Furthermore, our study further highlighted the proteomics and immunological function of EVs from mouse infected with
protoscoleces at different infection stages. We have laid a solid foundation for the role of EVs in cystic echinococcosis in the future research and supplemented a unique dataset for this |
|---|---|
| AbstractList | The globally distributed cystic echinococcosis (CE) is caused by the larval stage of Echinococcus granulosus (E. granulosus), a cosmopolitan and zoonotic disease with potentially life-threatening complications in humans. The emerging roles for extracellular vesicles (EVs) in parasitic infection include transferring proteins and modifying host cell gene expression to modulate host immune responses. Few studies focused on the host-derived EVs and its protein profiles. We focused on the EVs from mouse infected with E. granulosus at different stages. ExoQuick kit was used for isolating EVs from mouse plasma and ExoEasy Maxi kit was used for isolating protoscolex culture supernatant (PCS) and hydatid cyst fluid (HCF). Firstly, EVs were characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and immunoblot. Secondly, the proteins of plasma EVs were identified using liquid chromatography-tandem mass spectrometry (LC–MS/MS). The resulting LC–MS/MS data were processed using Maxquant search engine (v 1.5.2.8). Tandem mass spectra were researched against the mice and E. granulosus proteins database in the NCBI. The differentially expressed proteins are performed by proteomic label-free quantitative analysis and bioinformatics. Thirdly, in vitro experiment, the results of co-culture of plasma EVs and spleen mononuclear cells showed that 7W-EVs can increase the relative abundance of regulatory T (Treg) cells and IL-10. We further verified that EVs can be internalized by CD4+ and CD8+ T cells, B cells, and myeloid-derived suppressor cells (MDSC). These results implied host-derived EVs are multidirectional immune modulators. The findings can contribute to a better understanding of the role of host-derived EVs which are the optimal vehicle to transfer important cargo into host immune system. In addition, we have found several important proteins associated with E. granulosus and identified in infected mouse plasma at different stages. Furthermore, our study further highlighted the proteomics and immunological function of EVs from mouse infected with E. granulosus protoscoleces at different infection stages. We have laid a solid foundation for the role of EVs in cystic echinococcosis in the future research and supplemented a unique dataset for this E. granulosus. The globally distributed cystic echinococcosis (CE) is caused by the larval stage of Echinococcus granulosus ( E. granulosus ), a cosmopolitan and zoonotic disease with potentially life-threatening complications in humans. The emerging roles for extracellular vesicles (EVs) in parasitic infection include transferring proteins and modifying host cell gene expression to modulate host immune responses. Few studies focused on the host-derived EVs and its protein profiles. We focused on the EVs from mouse infected with E. granulosus at different stages. ExoQuick kit was used for isolating EVs from mouse plasma and ExoEasy Maxi kit was used for isolating protoscolex culture supernatant (PCS) and hydatid cyst fluid (HCF). Firstly, EVs were characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and immunoblot. Secondly, the proteins of plasma EVs were identified using liquid chromatography-tandem mass spectrometry (LC–MS/MS). The resulting LC–MS/MS data were processed using Maxquant search engine (v 1.5.2.8). Tandem mass spectra were researched against the mice and E. granulosus proteins database in the NCBI. The differentially expressed proteins are performed by proteomic label-free quantitative analysis and bioinformatics. Thirdly, in vitro experiment, the results of co-culture of plasma EVs and spleen mononuclear cells showed that 7W-EVs can increase the relative abundance of regulatory T (Treg) cells and IL-10. We further verified that EVs can be internalized by CD4 + and CD8 + T cells, B cells, and myeloid-derived suppressor cells (MDSC). These results implied host-derived EVs are multidirectional immune modulators. The findings can contribute to a better understanding of the role of host-derived EVs which are the optimal vehicle to transfer important cargo into host immune system. In addition, we have found several important proteins associated with E. granulosus and identified in infected mouse plasma at different stages. Furthermore, our study further highlighted the proteomics and immunological function of EVs from mouse infected with E. granulosus protoscoleces at different infection stages. We have laid a solid foundation for the role of EVs in cystic echinococcosis in the future research and supplemented a unique dataset for this E. granulosus. The globally distributed cystic echinococcosis (CE) is caused by the larval stage of ( ), a cosmopolitan and zoonotic disease with potentially life-threatening complications in humans. The emerging roles for extracellular vesicles (EVs) in parasitic infection include transferring proteins and modifying host cell gene expression to modulate host immune responses. Few studies focused on the host-derived EVs and its protein profiles. We focused on the EVs from mouse infected with at different stages. ExoQuick kit was used for isolating EVs from mouse plasma and ExoEasy Maxi kit was used for isolating protoscolex culture supernatant (PCS) and hydatid cyst fluid (HCF). Firstly, EVs were characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and immunoblot. Secondly, the proteins of plasma EVs were identified using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The resulting LC-MS/MS data were processed using Maxquant search engine (v 1.5.2.8). Tandem mass spectra were researched against the mice and proteins database in the NCBI. The differentially expressed proteins are performed by proteomic label-free quantitative analysis and bioinformatics. Thirdly, experiment, the results of co-culture of plasma EVs and spleen mononuclear cells showed that 7W-EVs can increase the relative abundance of regulatory T (Treg) cells and IL-10. We further verified that EVs can be internalized by CD4 and CD8 T cells, B cells, and myeloid-derived suppressor cells (MDSC). These results implied host-derived EVs are multidirectional immune modulators. The findings can contribute to a better understanding of the role of host-derived EVs which are the optimal vehicle to transfer important cargo into host immune system. In addition, we have found several important proteins associated with and identified in infected mouse plasma at different stages. Furthermore, our study further highlighted the proteomics and immunological function of EVs from mouse infected with protoscoleces at different infection stages. We have laid a solid foundation for the role of EVs in cystic echinococcosis in the future research and supplemented a unique dataset for this |
| Author | Zhao, Wei Bai, Min Zhou, Xiaojing Ding, Shuqin Zhao, Jiaqing Yang, Wenjuan Shi, Chunli Yang, Hui Gao, Xiaoping Wu, Jianwen Yin, Mei Zhang, Ying Nagai, Atsushi |
| AuthorAffiliation | 5 Research Center for Medical Science and Technology, Ningxia Medical University , Yinchuan , China 4 Department of Neurology, Shimane University Faculty of Medicine , Izumo , Japan 9 Department of Otolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University , Yinchuan , China 3 College of Clinical Medicine, Ningxia Medical University , Yinchuan , China 6 Ningxia Institute of Medical Science , Yinchuan , China 7 Ningxia Key Laboratory of Prevention and Control of Common Infectious Diseases , Yinchuan , China 2 Department of Molecular Biology, Shanghai Centre for Clinical Laboratory , Shanghai , China 10 Department of Medical Laboratory, School of Clinical Medicine, Ningxia Medical University , Yinchuan , China 1 School of Basic Medicine, Ningxia Medical University , Yinchuan , China 8 Department of Respiratory Medicine, General Hospital of Ningxia Medical University , Yinchuan , China |
| AuthorAffiliation_xml | – name: 1 School of Basic Medicine, Ningxia Medical University , Yinchuan , China – name: 5 Research Center for Medical Science and Technology, Ningxia Medical University , Yinchuan , China – name: 2 Department of Molecular Biology, Shanghai Centre for Clinical Laboratory , Shanghai , China – name: 4 Department of Neurology, Shimane University Faculty of Medicine , Izumo , Japan – name: 6 Ningxia Institute of Medical Science , Yinchuan , China – name: 7 Ningxia Key Laboratory of Prevention and Control of Common Infectious Diseases , Yinchuan , China – name: 8 Department of Respiratory Medicine, General Hospital of Ningxia Medical University , Yinchuan , China – name: 9 Department of Otolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University , Yinchuan , China – name: 3 College of Clinical Medicine, Ningxia Medical University , Yinchuan , China – name: 10 Department of Medical Laboratory, School of Clinical Medicine, Ningxia Medical University , Yinchuan , China |
| Author_xml | – sequence: 1 givenname: Chunli surname: Shi fullname: Shi, Chunli organization: Department of Molecular Biology, Shanghai Centre for Clinical Laboratory, Shanghai, China – sequence: 2 givenname: Xiaojing surname: Zhou fullname: Zhou, Xiaojing organization: Department of Neurology, Shimane University Faculty of Medicine, Izumo, Japan – sequence: 3 givenname: Wenjuan surname: Yang fullname: Yang, Wenjuan organization: College of Clinical Medicine, Ningxia Medical University, Yinchuan, China – sequence: 4 givenname: Jianwen surname: Wu fullname: Wu, Jianwen organization: School of Basic Medicine, Ningxia Medical University, Yinchuan, China – sequence: 5 givenname: Min surname: Bai fullname: Bai, Min organization: School of Basic Medicine, Ningxia Medical University, Yinchuan, China – sequence: 6 givenname: Ying surname: Zhang fullname: Zhang, Ying organization: School of Basic Medicine, Ningxia Medical University, Yinchuan, China – sequence: 7 givenname: Wei surname: Zhao fullname: Zhao, Wei organization: Ningxia Key Laboratory of Prevention and Control of Common Infectious Diseases, Yinchuan, China – sequence: 8 givenname: Hui surname: Yang fullname: Yang, Hui organization: Ningxia Key Laboratory of Prevention and Control of Common Infectious Diseases, Yinchuan, China – sequence: 9 givenname: Atsushi surname: Nagai fullname: Nagai, Atsushi organization: Department of Neurology, Shimane University Faculty of Medicine, Izumo, Japan – sequence: 10 givenname: Mei surname: Yin fullname: Yin, Mei organization: Department of Respiratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, China – sequence: 11 givenname: Xiaoping surname: Gao fullname: Gao, Xiaoping organization: Department of Otolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, China – sequence: 12 givenname: Shuqin surname: Ding fullname: Ding, Shuqin organization: Department of Medical Laboratory, School of Clinical Medicine, Ningxia Medical University, Yinchuan, China – sequence: 13 givenname: Jiaqing surname: Zhao fullname: Zhao, Jiaqing organization: Ningxia Key Laboratory of Prevention and Control of Common Infectious Diseases, Yinchuan, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35360110$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1098_rstb_2022_0447 crossref_primary_10_1016_j_micinf_2023_105147 crossref_primary_10_1371_journal_pntd_0010814 crossref_primary_10_3390_life13122286 crossref_primary_10_1051_parasite_2023060 |
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| ContentType | Journal Article |
| Copyright | Copyright © 2022 Shi, Zhou, Yang, Wu, Bai, Zhang, Zhao, Yang, Nagai, Yin, Gao, Ding and Zhao. Copyright © 2022 Shi, Zhou, Yang, Wu, Bai, Zhang, Zhao, Yang, Nagai, Yin, Gao, Ding and Zhao 2022 Shi, Zhou, Yang, Wu, Bai, Zhang, Zhao, Yang, Nagai, Yin, Gao, Ding and Zhao |
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| Keywords | extracellular vesicles host–parasite interactions immunomodulatory functions proteomics Echinococcus granulosus |
| Language | English |
| License | Copyright © 2022 Shi, Zhou, Yang, Wu, Bai, Zhang, Zhao, Yang, Nagai, Yin, Gao, Ding and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Celio Geraldo Freire-de-Lima, Federal University of Rio de Janeiro, Brazil; Hiba Al-Abodi, University of Al-Qadisiyah, Iraq; Justin Komguep Nono, Ministry of Scientific Research and Innovation, Cameroon This article was submitted to Parasite and Host, a section of the journal Frontiers in Cellular and Infection Microbiology Edited by: Giuseppe Palmisano, University of São Paulo, Brazil These authors have contributed equally to this work and share first authorship |
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), a cosmopolitan and zoonotic disease with potentially life-threatening... The globally distributed cystic echinococcosis (CE) is caused by the larval stage of Echinococcus granulosus ( E. granulosus ), a cosmopolitan and zoonotic... The globally distributed cystic echinococcosis (CE) is caused by the larval stage of Echinococcus granulosus (E. granulosus), a cosmopolitan and zoonotic... |
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| Title | Proteomic Analysis of Plasma-Derived Extracellular Vesicles From Mice With Echinococcus granulosus at Different Infection Stages and Their Immunomodulatory Functions |
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