Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3

• Published in: Oncogene Vol. 20; no. 41; pp. 5930 - 5939
• Main Authors: MCILHATTON, Michael A, BURROWS, James F, DONAGHY, Paul G, CHANDULOY, Severine, JOHNSTON, Patrick G, RUSSELL, S. E
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 13.09.2001; Nature Publishing Group
• Subjects: 3' Untranslated regions; Acute myeloid leukemia; Alternative Splicing; Amino Acid Sequence; Base Sequence; Biological and medical sciences; Cell division; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Chromosome 17; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 17 - genetics; Cytokinesis; Cytoskeletal Proteins - chemistry; Cytoskeletal Proteins - genetics; Exocytosis; Exons; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Neoplastic; Genes; Genome, Human; Genomics; GTP-Binding Proteins - chemistry; GTP-Binding Proteins - genetics; Humans; Insects; Isoforms; Leukemia; Molecular and cellular biology; Molecular Sequence Data; Neoplasm Proteins - genetics; Oncology; Ov/Br septin gene; Protein Isoforms - chemistry; Protein Isoforms - genetics; Proteins; RNA, Messenger - metabolism; Septin; Transcription; Human; Organization; Splicing; Gene expression; Genomics; Chromosome A

The Ov/Br septin gene, which is also a fusion partner of MLL in acute myeloid leukaemia, is a member of a family of novel GTP binding proteins that have been implicated in cytokinesis and exocytosis. In this study, we describe the genomic and transcriptional organization of this gene, detailing seve...