Noninvasive imaging in cancer immunotherapy: The way to precision medicine

• Published in: Cancer letters Vol. 466; pp. 13 - 22
• Main Authors: Du, Yang, Qi, Yafei, Jin, Zhengyu, Tian, Jie
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.12.2019; Elsevier Limited
• Subjects: Animals; Antigens; Antitumor activity; Apoptosis; Cancer; Cancer immunotherapy; Cancer therapies; Cancer Vaccines - therapeutic use; Chimeric antigen receptors; Cytotoxicity; Deoxyribonucleic acid; DNA; FDA approval; Gene expression; Humans; Immune checkpoint inhibitor; Immune checkpoint inhibitors; Immune system; Immunologic Factors - therapeutic use; Immunotherapy; Immunotherapy - methods; Immunotherapy, Adoptive; Ligands; Lymphocytes; Lymphocytes T; Medical research; Molecular imaging; Molecular Imaging - methods; Molecular Targeted Therapy; Neoplasms - immunology; Neoplasms - therapy; Oncology; Patients; Peptides; Precision Medicine; Proteins; Radiomics; T cell receptors; Tumor cells; Tumors; Vaccines; Molecular imaging; Precision medicine; Immune checkpoint inhibitor; Immunotherapy; Cancer

Molecular medicine requires a more precise treatment directed at molecular aberrations detected in tumors on an individual patient level. Immunotherapies empower the body's own immune system to confront tumor cells; however, their efficacy is often affected by tumor heterogeneity. Numerous noni...