In vitro examination of suspicious oral lesions using optical coherence tomography

• Published in: British journal of oral & maxillofacial surgery Vol. 48; no. 1; pp. 18 - 25
• Main Authors: Jerjes, Waseem, Upile, Tahwinder, Conn, Brendan, Hamdoon, Zaid, Betz, Christian S, McKenzie, Gordon, Radhi, Hani, Vourvachis, Michael, El Maaytah, Mohammed, Sandison, Ann, Jay, Amrita, Hopper, Colin
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.01.2010; Elsevier
• Subjects: Basement Membrane - pathology; Biological and medical sciences; Biopsy; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Dentistry; Diagnosis, Differential; Epithelium - pathology; Erythroplakia; Erythroplasia - diagnosis; Erythroplasia - pathology; Feasibility Studies; Humans; Image Processing, Computer-Assisted - methods; Interferometric tomographic imaging; Keratins - analysis; Leukoplakia; Leukoplakia, Oral - diagnosis; Leukoplakia, Oral - pathology; Medical sciences; Mouth Mucosa - pathology; Mouth Neoplasms - diagnosis; Mouth Neoplasms - pathology; OCT; Optical biopsy; Optical coherence tomography; Optical diagnostics; Oral cancer; Oral dysplasia; Oral Ulcer - diagnosis; Oral Ulcer - pathology; Otorhinolaryngology. Stomatology; Pilot Projects; Precancerous Conditions - diagnosis; Precancerous Conditions - pathology; Surgery; Swept-source Fourier-domain OCT; Tomography, Optical Coherence - instrumentation; Tomography, Optical Coherence - methods; Tongue Neoplasms - diagnosis; Tongue Neoplasms - pathology; OCT; Swept-source Fourier-domain OCT; Oral cancer; Optical biopsy; Optical coherence tomography; Interferometric tomographic imaging; Optical diagnostics; Erythroplakia; Oral dysplasia; Leukoplakia; Treatment; Radiodiagnosis; Stomatology; Surgery; Coherence; Oral administration; Tomography; Lesion; In vitro

Abstract We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were asse...