The p53-induced Gene Ei24 Is an Essential Component of the Basal Autophagy Pathway

• Published in: The Journal of biological chemistry Vol. 287; no. 50; pp. 42053 - 42063
• Main Authors: Zhao, Yan G., Zhao, Hongyu, Miao, Lin, Wang, Li, Sun, Fei, Zhang, Hong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.12.2012; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; autophagosome; Autophagy; Autophagy - physiology; Axons - metabolism; C. elegans; Hepatocyte; Hepatocytes - metabolism; Heredodegenerative Disorders, Nervous System - genetics; Heredodegenerative Disorders, Nervous System - metabolism; Mice; Mice, Transgenic; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Neurodegeneration; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oligodendrocytes; Oligodendroglia - metabolism; Organ Specificity - genetics; p53; Signal Transduction; Transcription Factor TFIIH; Transcription Factors - immunology; Transcription Factors - metabolism; C. elegans; Hepatocyte; Neurodegeneration; Oligodendrocytes; Autophagy; autophagosome; p53

Ei24 is a DNA damage response gene involved in growth suppression and apoptosis. The physiological function of Ei24, however, is poorly understood. Here we generated conditional knock-out mice of Ei24 and demonstrated that EI24 is an essential component of the basal autophagy pathway. Mice with neur...