NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein

• Published in: Cancer letters Vol. 451; pp. 156 - 167
• Main Authors: Li, Wan-Yu, Zhou, Hong-Zhong, Chen, Yao, Cai, Xue-Fei, Tang, Hua, Ren, Ji-Hua, Wai Wong, Vincent Kam, Kwan Law, Betty Yuen, Chen, Yong, Cheng, Sheng-Tao, Yu, Hai-Bo, Cai, Hao-Yang, Chen, Wei-Xian, Tang, Ni, Zhang, Wen-Lu, Tao, Na-Na, Yang, Qiu-Xia, Ren, Fang, He, Lin, Jiang, Hui, Huang, Ai-Long, Chen, Juan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.06.2019; Elsevier Limited
• Subjects: Animals; Antioxidants; Apoptosis; Breast cancer; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - pathology; Cell growth; Cell Line, Transformed; Cell proliferation; Colon; Gene expression; Hepatocellular carcinoma; Humans; Immunoglobulins; Kinases; Liver cancer; Liver Neoplasms - enzymology; Liver Neoplasms - pathology; Male; Mice; Mice, Inbred BALB C; Molecular modelling; NAD; NAD(P)H Dehydrogenase (Quinone) - genetics; NAD(P)H Dehydrogenase (Quinone) - metabolism; NQO1; Phosphorylation; Prostate cancer; Proteins; Quinone oxidoreductase; Skin cancer; Therapeutic applications; Tumorigenicity; X-linked inhibitor of apoptosis protein; X-Linked Inhibitor of Apoptosis Protein - metabolism; XIAP protein; United States > US; China; NQO1; Hepatocellular carcinoma; X-linked inhibitor of apoptosis protein; Apoptosis

NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme which is associated with poor prognosis in human breast, colon, lung and liver cancers. However, the molecular mechanisms underlying the pro-tumorigenic function of NQO1 remains unclear. This study investigated the function of NQO1 in...