RNA Virus Population Diversity, an Optimum for Maximal Fitness and Virulence

• Published in: The Journal of biological chemistry Vol. 289; no. 43; pp. 29531 - 29544
• Main Authors: Korboukh, Victoria K., Lee, Cheri A., Acevedo, Ashley, Vignuzzi, Marco, Xiao, Yinghong, Arnold, Jamie J., Hemperly, Stephen, Graci, Jason D., August, Avery, Andino, Raul, Cameron, Craig E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.10.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Base Sequence; Genetic Fitness; Genome, Viral - genetics; HeLa Cells; Humans; Immunity; Mice, Inbred ICR; Microbiology; Molecular Sequence Data; Mutation - genetics; Phenotype; Poliomyelitis - immunology; Poliomyelitis - virology; Poliovirus - enzymology; Poliovirus - genetics; Poliovirus - pathogenicity; Poliovirus - ultrastructure; RNA-Dependent RNA Polymerase - genetics; Virulence; Virus Assembly; Virus Replication; Viral Replication; Poliovirus; RNA Polymerase; RNA Virus; Viral Polymerase

The ability of an RNA virus to exist as a population of genetically distinct variants permits the virus to overcome events during infections that would otherwise limit virus multiplication or drive the population to extinction. Viral genetic diversity is created by the ribonucleotide misincorporatio...