Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 21; pp. 5540 - 5545
• Main Authors: Kervezee, Laura, Cuesta, Marc, Cermakian, Nicolas, Boivin, Diane B.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.05.2018
• Subjects: Adolescent; Adult; Biological activity; Biological Sciences; Blood; Cardiovascular disease; Circadian rhythm; Circadian Rhythm - physiology; Circadian rhythms; Computer Simulation; Data processing; Environmental impact; Female; Functional analysis; Gene expression; Health risks; Humans; Immune response; Immune response (cell-mediated); Immune system; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Male; Misalignment; Natural killer cells; Nervous system; Night shifts; Nighttime; Peripheral blood mononuclear cells; Ribonucleic acid; RNA; Shift work; Shift Work Schedule; Sleep; Sleep - physiology; Sleep Disorders, Circadian Rhythm - genetics; Sleep Disorders, Circadian Rhythm - physiopathology; Transcription factors; Transcriptome; Young Adult; transcriptomics; night shift work; chronobiology; circadian rhythms

Misalignment of the endogenous circadian timing system leads to disruption of physiological rhythms and may contribute to the development of the deleterious health effects associated with night shift work. However, the molecular underpinnings remain to be elucidated. Here, we investigated the effect...