A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 9; pp. 1 - 8
• Main Authors: Jiang, Xin, Labaudinière, Richard, Buxbaum, Joel N., Monteiro, Cecília, Novais, Marta, Coelho, Teresa, Kelly, Jeffery W.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 02.03.2021
• Subjects: Amyloid; Biological Sciences; Biomarkers; Degenerative diseases; Disease; Enzyme-linked immunosorbent assay; Fibrils; Monomers; Oligomers; Plasma levels; Plasmas (physics); Polyneuropathy; Pretreatment; Reduction; Transthyretin; early diagnosis; biomarker; NNTTR; response to therapy
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.2016072118

The transthyretin (TTR) amyloidoses (ATTR) are progressive, degenerative diseases resulting from dissociation of the TTR tetramer to monomers, which subsequently misfold and aggregate, forming a spectrum of aggregate structures including oligomers and amyloid fibrils. To determine whether circulatin...