Genetic polymorphism of carcinogen metabolic enzymes in oral submucous fibrosis

• Published in: Journal of Indian Academy of Oral Medicine and Radiology Vol. 34; no. 2; pp. 122 - 125
• Main Authors: Ramachandran, Sunu, Balan, Anita, Bose, C, Balaram, Prabha, Nityasri, V
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01.04.2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Biotransformation; Cancer; Carcinogens; cyp1a1; Cytochrome P-450; Cytochrome P450; Development and progression; Drug metabolism; Enzymes; Fibrosis; Gene polymorphism; Genes; Genetic aspects; Genetic diversity; genetic polymorphism; Genetic polymorphisms; Genetic research; Genetic transformation; gstm1; GSTM1 protein; Health aspects; Malignancy; Oncology, Experimental; oral submucous fibrosis; Physiological aspects; Polymorphism; Risk factors; India; CYP1A1; oral submucous fibrosis; GSTM1; genetic polymorphism

Background: Biotransformation plays a crucial role in carcinogen activity. Genetic polymorphisms in xenobiotic-metabolizing enzymes crucial to a carcinogen and drug metabolism lead to variations in their activity. These enzymes increase cancer risk by an altered action on environmental carcinogens....