Inflammation is independent of steatosis in a murine model of steatohepatitis

• Published in: Hepatology (Baltimore, Md.) Vol. 66; no. 1; pp. 108 - 123
• Main Authors: Wang, Wei, Xu, Ming‐Jiang, Cai, Yan, Zhou, Zhou, Cao, Haixia, Mukhopadhyay, Partha, Pacher, Pal, Zheng, Shusen, Gonzalez, Frank J., Gao, Bin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.07.2017
• Subjects: Analysis of Variance; Animal models; Animals; Binge Drinking - complications; Binge Drinking - metabolism; Biopsy, Needle; Cell activation; Cells, Cultured; Chemokine CXCL1 - metabolism; Chemokines; Cytokines; Diet, High-Fat; Disease Models, Animal; Ethanol; Ethanol - administration & dosage; Ethanol - adverse effects; Fatty liver; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - pathology; Gene deletion; Hepatocytes; Hepatocytes - cytology; Hepatocytes - metabolism; Hepatology; High fat diet; Immunohistochemistry; Inflammation; Inflammation - pathology; Inflammation - physiopathology; Interleukin 8; Lipid metabolism; Liver; Liver Function Tests; Male; Metastases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Obesity; Palmitic acid; Peroxisome proliferator-activated receptors; PPAR gamma - metabolism; Random Allocation; Rodents; Steatosis; Tumor necrosis factor

Obesity and alcohol consumption synergistically promote steatohepatitis, and neutrophil infiltration is believed to be associated with steatosis. However, the underlying mechanisms remain obscure. Peroxisome proliferator–activated receptor gamma (PPARγ) plays a complex role in lipid metabolism and i...