Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer’s disease

• Published in: CNS neuroscience & therapeutics Vol. 28; no. 4; pp. 580 - 592
• Main Authors: Xu, Yunlong, Jiang, Chenyu, Wu, Junyan, Liu, Peidong, Deng, Xiaofei, Zhang, Yadong, Peng, Bo, Zhu, Yingjie
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2022; John Wiley and Sons Inc
• Subjects: Alzheimer Disease - pathology; Alzheimer's disease; Amyloid; Animal cognition; Animal models; Animals; Brain; Carbohydrates; Cognitive ability; Cognitive Dysfunction - etiology; cognitive impairment; Dementia; Dementia disorders; Diet; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Ethanol; High carbohydrate diet; High fat diet; Humans; Inflammation; Ketogenesis; ketogenic diet; Laboratories; Low carbohydrate diet; Low fat diet; Memory; Mice; Mice, Transgenic; microglial activation; Neurodegenerative diseases; neuroinflammation; Neuroinflammatory Diseases; Nutrient deficiency; Original; Patients; Plaque, Amyloid; Proteins; Short term memory; Spatial discrimination learning; Spatial memory; Synapses; Therapeutic applications; Transgenic animals; Beijing China; China; cognitive impairment; ketogenic diet; neuroinflammation; Alzheimer's disease; microglial activation

Introduction Alzheimer's disease (AD) is the most common neurodegenerative disorder that causes dementia and affects millions of people worldwide. Although it has devastating outcomes for patients and tremendous economic costs to society, there is currently no effective treatment available. Aim...