Expression profiling of precuneus layer III cathepsin D‐immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability

• Published in: Journal of comparative neurology (1911) Vol. 528; no. 16; pp. 2748 - 2766
• Main Authors: He, Bin, Perez, Sylvia E., Lee, Sang H., Ginsberg, Stephen D., Malek‐Ahmadi, Michael, Mufson, Elliott J.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2020; Wiley Subscription Services, Inc
• Subjects: Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid; Autophagy; Autopsy; Brodmann's area; Cathepsin D; Cathepsin D - genetics; Cathepsin D - metabolism; Cognitive ability; Cognitive Dysfunction - genetics; Cognitive Dysfunction - pathology; Cortex (parietal); Cytoskeleton; Defects; Dementia disorders; DNA microarrays; expression profiling; Female; Gene Expression Profiling; Glutamic acid receptors; Glutamic acid receptors (metabotropic); Humans; Hydrolase; Laser Capture Microdissection; Male; microarray; Microarray Analysis; mild cognitive impairment; Neurodegenerative diseases; neurons; Neurotransmission; Parietal Lobe - pathology; Phagocytosis; precuneus; Pyramidal cells; Pyramidal Cells - metabolism; Pyramidal Cells - pathology; RRID; Signal Transduction; Tau protein; microarray; precuneus; expression profiling; mild cognitive impairment; Alzheimer's disease; RRID; laser capture microdissection; neurons

The precuneus (PreC; Brodmann area 7), a key hub within the default mode network (DMN) displays amyloid and tau‐containing neurofibrillary tangle (NFT) pathology during the onset of Alzheimer's disease (AD). PreC layer III projection neurons contain lysosomal hydrolase cathepsin D (CatD), a mar...