Distribution of ACE2, CD147, CD26, and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

• Published in: Allergy (Copenhagen) Vol. 75; no. 11; pp. 2829 - 2845
• Main Authors: Radzikowska, Urszula, Ding, Mei, Tan, Ge, Zhakparov, Damir, Peng, Yaqi, Wawrzyniak, Paulina, Wang, Ming, Li, Shuo, Morita, Hideaki, Altunbulakli, Can, Reiger, Matthias, Neumann, Avidan U., Lunjani, Nonhlanhla, Traidl‐Hoffmann, Claudia, Nadeau, Kari C., O’Mahony, Liam, Akdis, Cezmi, Sokolowska, Milena
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.11.2020; John Wiley and Sons Inc
• Subjects: ACE2; Adolescent; Adult; Age; Age Factors; Aged; Alveoli; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - immunology; Asthma; Asthma - epidemiology; Asthma - genetics; Asthma - immunology; Atopic dermatitis; Basigin - genetics; Basigin - immunology; Biopsy; Bronchus; CD147 antigen; CD4 antigen; CD8 antigen; Child; Child, Preschool; Children; Chronic Disease - epidemiology; Chronic obstructive pulmonary disease; Comorbidity; COPD; COVID-19; COVID-19 - epidemiology; COVID-19 - genetics; COVID-19 - immunology; COVID‐19 children; Dipeptidyl Peptidase 4 - genetics; Dipeptidyl Peptidase 4 - immunology; Dipeptidyl-peptidase IV; Epithelial cells; Epithelium; Female; Gender; Gene expression; Gene Expression - genetics; Humans; Hypertension; Hypertension - epidemiology; Hypertension - genetics; Hypertension - immunology; Immunity, Innate - immunology; Infant; Leukocytes (mononuclear); Leukocytes (neutrophilic); Lymphocytes B; Lymphocytes T; Male; Middle Aged; Monocytes; Morbidity; Obesity; Obesity - epidemiology; Obesity - genetics; Obesity - immunology; Original; ORIGINAL ARTICLES; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - immunology; Ribonucleic acid; Risk Factors; RNA; SARS receptor; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Skin diseases; Young Adult; COVID-19; COVID-19 children; asthma; hypertension; SARS receptor; obesity; COPD

Background Morbidity and mortality from COVID‐19 caused by novel coronavirus SARS‐CoV‐2 is accelerating worldwide, and novel clinical presentations of COVID‐19 are often reported. The range of human cells and tissues targeted by SARS‐CoV‐2, its potential receptors and associated regulating factors a...